Detailed information of TA system TA226389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 743057..743634
• Replicon: chromosome
• Accession: NZ_CP087856
• Organism: Moraxella bovis strain SAM57987

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP115_RS03925
• Protein ID: WP_078275234.1
• Coordinates: 743299..743634 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP115_RS03920
• Protein ID: WP_078275235.1
• Coordinates: 743057..743299 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP115_RS03895 (LP115_03880)	738956..739378	-	423	WP_078275239.1	hypothetical protein	-
LP115_RS03900 (LP115_03885)	739387..739692	-	306	WP_078275238.1	YciI family protein	-
LP115_RS03905 (LP115_03890)	739852..740478	-	627	WP_078275237.1	septation protein IspZ	-
LP115_RS03910 (LP115_03895)	740667..741389	+	723	WP_078275236.1	tRNA pseudouridine(65) synthase TruC	-
LP115_RS03915 (LP115_03900)	741771..742850	-	1080	WP_029103111.1	3-deoxy-7-phosphoheptulonate synthase	-
LP115_RS03920 (LP115_03905)	743057..743299	+	243	WP_078275235.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP115_RS03925 (LP115_03910)	743299..743634	+	336	WP_078275234.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP115_RS03930 (LP115_03915)	743696..744691	+	996	WP_208624081.1	polyprenyl synthetase family protein	-
LP115_RS03935 (LP115_03920)	744763..744951	+	189	WP_143821748.1	hypothetical protein	-
LP115_RS03940 (LP115_03925)	745041..747185	-	2145	WP_264684081.1	cation-translocating P-type ATPase	-
LP115_RS03945 (LP115_03930)	747350..747934	-	585	WP_112741954.1	hypothetical protein	-
LP115_RS03950 (LP115_03935)	748094..748294	-	201	WP_112741955.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-63)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13059.98 Da
• Isoelectric Point: 8.8194

>T226389 WP_078275234.1 NZ_CP087856:743299-743634 [Moraxella bovis]
MCELMYELEFDERALKEWQKLGDTIKTQFKKRLAKVLKNPHIIANRLSGGQNLYKINFRSAGYRLVYQVEDDKVVVFVIV
MGKREKNAVYDTAEEWLAERQSDNQDTQSVK

Nucleotide

• Length: 336 bp

>T226389 NZ_CP122454:4703979-4704443 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTCGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9034.47 Da
• Isoelectric Point: 4.7527

>AT226389 WP_078275235.1 NZ_CP087856:743057-743299 [Moraxella bovis]
MANIVARVDDDLKAQSFLVLQELGVTPSELIRQTLQYVAYHKKLPFKTVVLTDEDSELLALAKERLDNPAPRIKVSLDEL

Nucleotide

• Length: 243 bp

>AT226389 NZ_CP122454:4703644-4703979 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTC
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA