Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 638322..638971 Replicon chromosome
Accession NZ_CP087856
Organism Moraxella bovis strain SAM57987

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP115_RS03300 Protein ID WP_078274052.1
Coordinates 638570..638971 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP115_RS03295 Protein ID WP_112741908.1
Coordinates 638322..638555 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP115_RS03275 (LP115_03265) 633718..634167 - 450 WP_264676133.1 cytochrome c -
LP115_RS03280 (LP115_03270) 634349..635341 - 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP115_RS03285 (LP115_03275) 635361..635954 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP115_RS03290 (LP115_03280) 636175..638274 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP115_RS03295 (LP115_03285) 638322..638555 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP115_RS03300 (LP115_03290) 638570..638971 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP115_RS03305 (LP115_03295) 639495..639995 + 501 WP_112741909.1 WG repeat-containing protein -
LP115_RS03310 (LP115_03300) 640117..640947 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP115_RS03315 (LP115_03305) 641046..641735 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP115_RS03325 (LP115_03315) 642471..642890 - 420 WP_078274047.1 S4 domain-containing protein -
LP115_RS03330 (LP115_03320) 642887..643063 - 177 WP_228157829.1 ASCH domain-containing protein -
LP115_RS03335 (LP115_03325) 643082..643315 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226388 WP_078274052.1 NZ_CP087856:638570-638971 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226388 NZ_CP122454:4483744-4484121 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCATACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226388 WP_112741908.1 NZ_CP087856:638322-638555 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226388 NZ_CP122454:4483323-4483697 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGGCCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References