Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 477916..478574 Replicon chromosome
Accession NZ_CP087856
Organism Moraxella bovis strain SAM57987

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP115_RS02500 Protein ID WP_078274940.1
Coordinates 477916..478104 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP115_RS02505 Protein ID WP_112741846.1
Coordinates 478167..478574 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP115_RS02445 (LP115_02435) 473317..473736 - 420 WP_112741841.1 S24 family peptidase -
LP115_RS02450 (LP115_02440) 473733..474020 - 288 WP_078274962.1 ORF6C domain-containing protein -
LP115_RS02455 (LP115_02445) 474215..474514 - 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP115_RS02460 (LP115_02450) 474679..474888 + 210 WP_078274960.1 hypothetical protein -
LP115_RS02465 (LP115_02455) 474903..475094 + 192 WP_264676101.1 DNA-binding protein -
LP115_RS02470 (LP115_02460) 475103..475303 + 201 WP_264676324.1 hypothetical protein -
LP115_RS02475 (LP115_02465) 475381..476133 + 753 WP_078274945.1 hypothetical protein -
LP115_RS02480 (LP115_02470) 476177..476521 - 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP115_RS02485 (LP115_02475) 476644..476850 + 207 WP_264676102.1 DNA-binding protein -
LP115_RS02490 (LP115_02480) 476957..477556 + 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP115_RS02495 (LP115_02485) 477558..477773 + 216 WP_078274941.1 hypothetical protein -
LP115_RS02500 (LP115_02490) 477916..478104 + 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP115_RS02505 (LP115_02495) 478167..478574 + 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP115_RS02510 (LP115_02500) 478650..479621 + 972 WP_112741847.1 phage tail tape measure protein -
LP115_RS02515 (LP115_02505) 479618..479950 + 333 WP_112741848.1 hypothetical protein -
LP115_RS02520 (LP115_02510) 479884..480321 + 438 WP_162860346.1 hypothetical protein -
LP115_RS02525 (LP115_02515) 480375..481181 + 807 WP_112741850.1 hypothetical protein -
LP115_RS02530 (LP115_02520) 481182..481526 + 345 WP_078274937.1 hypothetical protein -
LP115_RS02535 (LP115_02525) 481514..483343 + 1830 WP_078274936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 465938..487811 21873


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226387 WP_078274940.1 NZ_CP087856:477916-478104 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226387 NZ_CP122454:c4358281-4357874 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226387 WP_112741846.1 NZ_CP087856:478167-478574 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226387 NZ_CP122454:c4358528-4358262 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References