Detailed information of TA system TA226384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2422130..2422782
• Replicon: chromosome
• Accession: NZ_CP087854
• Organism: Moraxella bovis strain SAM57990

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP113_RS12370
• Protein ID: WP_078275188.1
• Coordinates: 2422130..2422522 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP113_RS12375
• Protein ID: WP_078275189.1
• Coordinates: 2422519..2422782 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP113_RS12335 (LP113_12245)	2417222..2418163	+	942	WP_078275181.1	hydroxymethylbilane synthase	-
LP113_RS12340 (LP113_12250)	2418209..2419087	+	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP113_RS12345 (LP113_12255)	2419118..2420140	+	1023	WP_078275183.1	hypothetical protein	-
LP113_RS12350 (LP113_12260)	2420220..2420678	+	459	WP_078275184.1	acyl-CoA thioesterase	-
LP113_RS12355 (LP113_12265)	2420675..2420911	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP113_RS12360 (LP113_12270)	2420914..2421480	+	567	WP_078275186.1	hypothetical protein	-
LP113_RS12365 (LP113_12275)	2421477..2422007	-	531	WP_078275187.1	HI_0552 family protein	-
LP113_RS12370 (LP113_12280)	2422130..2422522	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP113_RS12375 (LP113_12285)	2422519..2422782	-	264	WP_078275189.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LP113_RS12380 (LP113_12290)	2422862..2424121	-	1260	WP_078275190.1	replication-associated recombination protein A	-
LP113_RS12385 (LP113_12295)	2424100..2424873	-	774	WP_078275191.1	hypothetical protein	-
LP113_RS12390 (LP113_12300)	2424924..2425364	+	441	WP_208624064.1	type IV secretion protein Rhs	-
LP113_RS12395 (LP113_12305)	2425429..2425701	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP113_RS12400 (LP113_12310)	2425694..2425987	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP113_RS12405 (LP113_12315)	2426131..2427465	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226384 WP_078275188.1 NZ_CP087854:c2422522-2422130 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226384 NZ_CP122454:c3430897-3430646 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10183.52 Da
• Isoelectric Point: 6.3724

>AT226384 WP_078275189.1 NZ_CP087854:c2422782-2422519 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKTFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226384 NZ_CP122454:c3430649-3430395 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA