Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2154180..2154829 Replicon chromosome
Accession NZ_CP087854
Organism Moraxella bovis strain SAM57990

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP113_RS11010 Protein ID WP_078274052.1
Coordinates 2154180..2154581 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP113_RS11015 Protein ID WP_112741908.1
Coordinates 2154596..2154829 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP113_RS10975 (LP113_10890) 2149836..2150069 + 234 WP_112741910.1 ASCH domain-containing protein -
LP113_RS10980 (LP113_10895) 2150088..2150264 + 177 WP_228157829.1 ASCH domain-containing protein -
LP113_RS10985 (LP113_10900) 2150261..2150680 + 420 WP_078274047.1 S4 domain-containing protein -
LP113_RS10995 (LP113_10910) 2151416..2152105 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP113_RS11000 (LP113_10915) 2152204..2153034 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP113_RS11005 (LP113_10920) 2153156..2153656 - 501 WP_112741909.1 WG repeat-containing protein -
LP113_RS11010 (LP113_10925) 2154180..2154581 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP113_RS11015 (LP113_10930) 2154596..2154829 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP113_RS11020 (LP113_10935) 2154877..2156976 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP113_RS11025 (LP113_10940) 2157197..2157790 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP113_RS11030 (LP113_10945) 2157810..2158802 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP113_RS11035 (LP113_10950) 2158984..2159433 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226383 WP_078274052.1 NZ_CP087854:c2154581-2154180 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226383 NZ_CP122454:c3430649-3430395 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226383 WP_112741908.1 NZ_CP087854:c2154829-2154596 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226383 NZ_CP122454:c3430897-3430646 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References