Detailed information of TA system TA226382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2049253..2049830
• Replicon: chromosome
• Accession: NZ_CP087854
• Organism: Moraxella bovis strain SAM57990

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP113_RS10380
• Protein ID: WP_078275234.1
• Coordinates: 2049253..2049588 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP113_RS10385
• Protein ID: WP_078275235.1
• Coordinates: 2049588..2049830 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP113_RS10355 (LP113_10275)	2044594..2044794	+	201	WP_112741955.1	hypothetical protein	-
LP113_RS10360 (LP113_10280)	2045007..2045537	+	531	WP_264684205.1	hypothetical protein	-
LP113_RS10365 (LP113_10285)	2045702..2047846	+	2145	WP_264684206.1	cation-translocating P-type ATPase	-
LP113_RS10370 (LP113_10290)	2047936..2048172	-	237	WP_264684207.1	hypothetical protein	-
LP113_RS10375 (LP113_10295)	2048196..2049191	-	996	WP_208624081.1	polyprenyl synthetase family protein	-
LP113_RS10380 (LP113_10300)	2049253..2049588	-	336	WP_078275234.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP113_RS10385 (LP113_10305)	2049588..2049830	-	243	WP_078275235.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP113_RS10390 (LP113_10310)	2050037..2051116	+	1080	WP_029103111.1	3-deoxy-7-phosphoheptulonate synthase	-
LP113_RS10395 (LP113_10315)	2051498..2052220	-	723	WP_078275236.1	tRNA pseudouridine(65) synthase TruC	-
LP113_RS10400 (LP113_10320)	2052409..2053035	+	627	WP_078275237.1	septation protein IspZ	-
LP113_RS10405 (LP113_10325)	2053195..2053500	+	306	WP_078275238.1	YciI family protein	-
LP113_RS10410 (LP113_10330)	2053509..2053931	+	423	WP_078275239.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-63)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13059.98 Da
• Isoelectric Point: 8.8194

>T226382 WP_078275234.1 NZ_CP087854:c2049588-2049253 [Moraxella bovis]
MCELMYELEFDERALKEWQKLGDTIKTQFKKRLAKVLKNPHIIANRLSGGQNLYKINFRSAGYRLVYQVEDDKVVVFVIV
MGKREKNAVYDTAEEWLAERQSDNQDTQSVK

Nucleotide

• Length: 336 bp

>T226382 NZ_CP122454:3420200-3420574 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9034.47 Da
• Isoelectric Point: 4.7527

>AT226382 WP_078275235.1 NZ_CP087854:c2049830-2049588 [Moraxella bovis]
MANIVARVDDDLKAQSFLVLQELGVTPSELIRQTLQYVAYHKKLPFKTVVLTDEDSELLALAKERLDNPAPRIKVSLDEL

Nucleotide

• Length: 243 bp

>AT226382 NZ_CP122454:3419743-3420111 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA