Detailed information of TA system TA226380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1829592..1830144
• Replicon: chromosome
• Accession: NZ_CP087854
• Organism: Moraxella bovis strain SAM57990

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP113_RS09190
• Protein ID: WP_029102268.1
• Coordinates: 1829592..1829870 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP113_RS09195
• Protein ID: WP_078273473.1
• Coordinates: 1829857..1830144 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP113_RS09160 (LP113_09085)	1825579..1826355	-	777	WP_078273467.1	nucleotidyltransferase domain-containing protein	-
LP113_RS09165 (LP113_09090)	1826467..1826817	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP113_RS09170 (LP113_09095)	1826965..1827480	+	516	WP_078273469.1	hypothetical protein	-
LP113_RS09175 (LP113_09100)	1827554..1827763	+	210	WP_264678116.1	hypothetical protein	-
LP113_RS09180 (LP113_09105)	1827976..1828641	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP113_RS09185 (LP113_09110)	1828841..1829497	+	657	WP_078273472.1	YqiJ family protein	-
LP113_RS09190 (LP113_09115)	1829592..1829870	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP113_RS09195 (LP113_09120)	1829857..1830144	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP113_RS09200 (LP113_09125)	1830154..1831884	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP113_RS09205	1831928..1832053	-	126	WP_264676709.1	hypothetical protein	-
LP113_RS09210 (LP113_09130)	1832082..1833581	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP113_RS09215 (LP113_09135)	1833660..1834709	-	1050	WP_264683526.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226380 WP_029102268.1 NZ_CP087854:1829592-1829870 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226380 NZ_CP087854:1829592-1829870 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226380 WP_078273473.1 NZ_CP087854:1829857-1830144 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226380 NZ_CP087854:1829857-1830144 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3