Detailed information of TA system TA226379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1618046..1618535
• Replicon: chromosome
• Accession: NZ_CP087854
• Organism: Moraxella bovis strain SAM57990

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP113_RS07955
• Protein ID: WP_264676856.1
• Coordinates: 1618046..1618303 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LP113_RS07960
• Protein ID: WP_228157840.1
• Coordinates: 1618293..1618535 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP113_RS07935 (LP113_07870)	1613074..1613922	+	849	WP_264676852.1	hypothetical protein	-
LP113_RS07940 (LP113_07875)	1614025..1616511	+	2487	WP_264684011.1	alpha/beta hydrolase	-
LP113_RS07945 (LP113_07880)	1616608..1617411	-	804	WP_264676854.1	UDP-2,3-diacylglucosamine diphosphatase	-
LP113_RS07950 (LP113_07885)	1617478..1617987	-	510	WP_264676855.1	peptidylprolyl isomerase	-
LP113_RS07955 (LP113_07890)	1618046..1618303	-	258	WP_264676856.1	Txe/YoeB family addiction module toxin	Toxin
LP113_RS07960 (LP113_07895)	1618293..1618535	-	243	WP_228157840.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LP113_RS07965 (LP113_07900)	1618580..1618744	+	165	WP_158079593.1	hypothetical protein	-
LP113_RS07970 (LP113_07905)	1618826..1619113	-	288	WP_115005096.1	DUF1315 family protein	-
LP113_RS07975 (LP113_07910)	1619136..1620083	-	948	WP_264676857.1	DUF853 domain-containing protein	-
LP113_RS07980 (LP113_07915)	1620070..1620486	-	417	WP_264676858.1	DUF853 domain-containing protein	-
LP113_RS07985 (LP113_07920)	1620399..1620656	-	258	WP_264676404.1	DUF853 domain-containing protein	-
LP113_RS07990 (LP113_07925)	1620874..1621281	-	408	WP_264676859.1	bestrophin family protein	-
LP113_RS07995 (LP113_07930)	1621271..1621483	-	213	WP_264676860.1	bestrophin family protein	-
LP113_RS08000 (LP113_07935)	1621480..1622277	-	798	WP_264676861.1	polyphenol oxidase family protein	-
LP113_RS08005 (LP113_07940)	1622396..1623445	-	1050	WP_264689785.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10488.00 Da
• Isoelectric Point: 8.1158

>T226379 WP_264676856.1 NZ_CP087854:c1618303-1618046 [Moraxella bovis]
MRIRWFDEVWEDYLYWQSQDKKTIKRINTLIKDCRRDPFDGIGKPEPLKYNLTGYWLRRINDANRLVYCCESETLIISCR
HHYEA

Nucleotide

• Length: 258 bp

>T226379 NZ_CP122454:c2792026-2791748 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9134.23 Da
• Isoelectric Point: 6.2120

>AT226379 WP_228157840.1 NZ_CP087854:c1618535-1618293 [Moraxella bovis]
MNYSEFRQNLASALDYVQDSHAPVIVKRGKHSAVVISLDEYNAFKETDYLLSNPANAEHLMRGVQAVKNRQLTQRDLIED

Nucleotide

• Length: 243 bp

>AT226379 NZ_CP122454:c2791748-2791464 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA