Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1477652..1478309 Replicon chromosome
Accession NZ_CP087854
Organism Moraxella bovis strain SAM57990

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP113_RS07250 Protein ID WP_264676287.1
Coordinates 1477652..1477834 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP113_RS07255 Protein ID WP_264676286.1
Coordinates 1477896..1478309 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP113_RS07225 (LP113_07165) 1473625..1475022 - 1398 WP_264676292.1 phage terminase large subunit -
LP113_RS07230 (LP113_07170) 1475022..1475561 - 540 WP_264676291.1 terminase small subunit -
LP113_RS07235 (LP113_07175) 1475675..1475884 + 210 WP_264676290.1 hypothetical protein -
LP113_RS07240 (LP113_07180) 1475921..1476121 + 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP113_RS07245 (LP113_07185) 1476548..1477252 - 705 WP_264676288.1 BRO family protein -
LP113_RS07250 (LP113_07190) 1477652..1477834 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP113_RS07255 (LP113_07195) 1477896..1478309 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP113_RS07260 (LP113_07200) 1478457..1478720 - 264 WP_264689774.1 hypothetical protein -
LP113_RS07265 (LP113_07205) 1478704..1478925 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP113_RS07270 (LP113_07210) 1478922..1479077 - 156 WP_264683498.1 hypothetical protein -
LP113_RS07275 (LP113_07215) 1479214..1479699 - 486 WP_078273444.1 recombination protein NinB -
LP113_RS07280 (LP113_07220) 1479763..1480440 - 678 WP_264682991.1 Bro-N domain-containing protein -
LP113_RS07285 (LP113_07225) 1481102..1481299 + 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP113_RS07290 (LP113_07230) 1481346..1481624 - 279 WP_264689775.1 hypothetical protein -
LP113_RS07295 (LP113_07235) 1481621..1482028 - 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP113_RS07300 (LP113_07240) 1482025..1482633 - 609 WP_264676191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1421791..1517122 95331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226378 WP_264676287.1 NZ_CP087854:1477652-1477834 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226378 NZ_CP122454:c2559414-2559307 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226378 WP_264676286.1 NZ_CP087854:1477896-1478309 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226378 NZ_CP122454:2559467-2559528 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References