Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 574051..574709 | Replicon | chromosome |
| Accession | NZ_CP087854 | ||
| Organism | Moraxella bovis strain SAM57990 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP113_RS02910 | Protein ID | WP_078274940.1 |
| Coordinates | 574051..574239 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP113_RS02915 | Protein ID | WP_112741846.1 |
| Coordinates | 574302..574709 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP113_RS02855 (LP113_02845) | 569452..569871 | - | 420 | WP_112741841.1 | S24 family peptidase | - |
| LP113_RS02860 (LP113_02850) | 569868..570155 | - | 288 | WP_264689843.1 | hypothetical protein | - |
| LP113_RS02865 (LP113_02855) | 570350..570649 | - | 300 | WP_078274961.1 | helix-turn-helix transcriptional regulator | - |
| LP113_RS02870 (LP113_02860) | 570814..571023 | + | 210 | WP_078274960.1 | hypothetical protein | - |
| LP113_RS02875 (LP113_02865) | 571038..571229 | + | 192 | WP_264676101.1 | DNA-binding protein | - |
| LP113_RS02880 (LP113_02870) | 571238..571438 | + | 201 | WP_264676324.1 | hypothetical protein | - |
| LP113_RS02885 (LP113_02875) | 571516..572268 | + | 753 | WP_078274945.1 | hypothetical protein | - |
| LP113_RS02890 (LP113_02880) | 572312..572656 | - | 345 | WP_078274944.1 | helix-turn-helix transcriptional regulator | - |
| LP113_RS02895 (LP113_02885) | 572779..572985 | + | 207 | WP_264676102.1 | DNA-binding protein | - |
| LP113_RS02900 (LP113_02890) | 573092..573691 | + | 600 | WP_078274942.1 | antA/AntB antirepressor family protein | - |
| LP113_RS02905 (LP113_02895) | 573693..573908 | + | 216 | WP_078274941.1 | hypothetical protein | - |
| LP113_RS02910 (LP113_02900) | 574051..574239 | + | 189 | WP_078274940.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP113_RS02915 (LP113_02905) | 574302..574709 | + | 408 | WP_112741846.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP113_RS02920 (LP113_02910) | 574785..575756 | + | 972 | WP_112741847.1 | phage tail tape measure protein | - |
| LP113_RS02925 (LP113_02915) | 575753..576085 | + | 333 | WP_112741848.1 | hypothetical protein | - |
| LP113_RS02930 (LP113_02920) | 576019..576456 | + | 438 | WP_162860346.1 | hypothetical protein | - |
| LP113_RS02935 (LP113_02925) | 576510..577316 | + | 807 | WP_264684230.1 | hypothetical protein | - |
| LP113_RS02940 (LP113_02930) | 577317..577661 | + | 345 | WP_078274937.1 | hypothetical protein | - |
| LP113_RS02945 (LP113_02935) | 577649..579478 | + | 1830 | WP_078274936.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | hlyB | 569452..628337 | 58885 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7047.13 Da Isoelectric Point: 10.3659
>T226377 WP_078274940.1 NZ_CP087854:574051-574239 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
Download Length: 189 bp
>T226377 NZ_CP122454:2315191-2315571 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14756.85 Da Isoelectric Point: 4.2244
>AT226377 WP_112741846.1 NZ_CP087854:574302-574709 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
Download Length: 408 bp
>AT226377 NZ_CP122454:2314770-2315144 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|