Detailed information of TA system TA226375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2301471..2302029
• Replicon: chromosome
• Accession: NZ_CP087851
• Organism: Moraxella bovis strain SAM57991

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP094_RS11805
• Protein ID: WP_228157760.1
• Coordinates: 2301471..2301743 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP094_RS11810
• Protein ID: WP_029103533.1
• Coordinates: 2301736..2302029 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP094_RS11765 (LP094_11665)	2296685..2296921	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP094_RS11770 (LP094_11670)	2296924..2297490	+	567	WP_078275186.1	hypothetical protein	-
LP094_RS11775 (LP094_11675)	2297487..2298017	-	531	WP_078275187.1	HI_0552 family protein	-
LP094_RS11780 (LP094_11680)	2298140..2298532	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP094_RS11785 (LP094_11685)	2298529..2298792	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP094_RS11790 (LP094_11690)	2298872..2300131	-	1260	WP_264675983.1	replication-associated recombination protein A	-
LP094_RS11795 (LP094_11695)	2300489..2300866	-	378	WP_264675984.1	hypothetical protein	-
LP094_RS11800 (LP094_11700)	2300951..2301406	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP094_RS11805 (LP094_11705)	2301471..2301743	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP094_RS11810 (LP094_11710)	2301736..2302029	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP094_RS11815 (LP094_11715)	2302173..2303507	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP094_RS11820 (LP094_11720)	2303716..2304432	-	717	WP_078275193.1	hypothetical protein	-
LP094_RS11825 (LP094_11725)	2304453..2305064	-	612	WP_112741794.1	methyltransferase	-
LP094_RS11830 (LP094_11730)	2305184..2306518	+	1335	WP_078275195.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226375 WP_228157760.1 NZ_CP087851:c2301743-2301471 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226375 NZ_CP122454:1334875-1335273 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226375 WP_029103533.1 NZ_CP087851:c2302029-2301736 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226375 NZ_CP122454:1334579-1334872 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6