Detailed information of TA system TA226374

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2298140..2298792
• Replicon: chromosome
• Accession: NZ_CP087851
• Organism: Moraxella bovis strain SAM57991

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP094_RS11780
• Protein ID: WP_078275188.1
• Coordinates: 2298140..2298532 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP094_RS11785
• Protein ID: WP_264675982.1
• Coordinates: 2298529..2298792 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP094_RS11745 (LP094_11645)	2293232..2294173	+	942	WP_078275181.1	hydroxymethylbilane synthase	-
LP094_RS11750 (LP094_11650)	2294219..2295097	+	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP094_RS11755 (LP094_11655)	2295128..2296150	+	1023	WP_078275183.1	hypothetical protein	-
LP094_RS11760 (LP094_11660)	2296230..2296688	+	459	WP_078275184.1	acyl-CoA thioesterase	-
LP094_RS11765 (LP094_11665)	2296685..2296921	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP094_RS11770 (LP094_11670)	2296924..2297490	+	567	WP_078275186.1	hypothetical protein	-
LP094_RS11775 (LP094_11675)	2297487..2298017	-	531	WP_078275187.1	HI_0552 family protein	-
LP094_RS11780 (LP094_11680)	2298140..2298532	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP094_RS11785 (LP094_11685)	2298529..2298792	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP094_RS11790 (LP094_11690)	2298872..2300131	-	1260	WP_264675983.1	replication-associated recombination protein A	-
LP094_RS11795 (LP094_11695)	2300489..2300866	-	378	WP_264675984.1	hypothetical protein	-
LP094_RS11800 (LP094_11700)	2300951..2301406	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP094_RS11805 (LP094_11705)	2301471..2301743	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP094_RS11810 (LP094_11710)	2301736..2302029	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP094_RS11815 (LP094_11715)	2302173..2303507	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226374 WP_078275188.1 NZ_CP087851:c2298532-2298140 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226374 NZ_CP122454:1096473-1096787 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226374 WP_264675982.1 NZ_CP087851:c2298792-2298529 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226374 NZ_CP122454:1096237-1096470 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG