Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2058733..2059309 Replicon chromosome
Accession NZ_CP087851
Organism Moraxella bovis strain SAM57991

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP094_RS10525 Protein ID WP_264676341.1
Coordinates 2058733..2058993 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP094_RS10530 Protein ID WP_078273964.1
Coordinates 2058974..2059309 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP094_RS10510 (LP094_10435) 2053764..2055839 + 2076 WP_264675941.1 NAD-dependent DNA ligase LigA -
LP094_RS10515 (LP094_10440) 2056352..2057737 + 1386 WP_078273966.1 APC family permease -
LP094_RS10520 (LP094_10445) 2057827..2058534 - 708 WP_264675942.1 ParA family protein -
LP094_RS10525 (LP094_10450) 2058733..2058993 + 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP094_RS10530 (LP094_10455) 2058974..2059309 + 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP094_RS10535 (LP094_10460) 2059493..2060077 - 585 Protein_2062 TetR/AcrR family transcriptional regulator -
LP094_RS10540 (LP094_10465) 2060339..2061520 + 1182 WP_078274027.1 fatty acid desaturase -
LP094_RS10545 (LP094_10470) 2062166..2062933 + 768 WP_112742541.1 carbonic anhydrase family protein -
LP094_RS10550 (LP094_10475) 2063067..2064149 + 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226373 WP_264676341.1 NZ_CP087851:2058733-2058993 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226373 NZ_CP122454:921997-922374 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226373 WP_078273964.1 NZ_CP087851:2058974-2059309 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226373 NZ_CP122454:921539-921907 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References