Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1310915..1311572 Replicon chromosome
Accession NZ_CP087851
Organism Moraxella bovis strain SAM57991

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP094_RS07020 Protein ID WP_264676287.1
Coordinates 1311390..1311572 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP094_RS07015 Protein ID WP_264676286.1
Coordinates 1310915..1311328 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP094_RS06960 (LP094_06920) 1306051..1306749 + 699 WP_264676280.1 antA/AntB antirepressor family protein -
LP094_RS06965 (LP094_06925) 1306746..1307063 + 318 WP_078273437.1 hypothetical protein -
LP094_RS06970 (LP094_06930) 1307060..1307947 + 888 WP_264676190.1 replication protein -
LP094_RS06975 (LP094_06935) 1307940..1308548 + 609 WP_264676191.1 hypothetical protein -
LP094_RS06980 (LP094_06940) 1308545..1308940 + 396 WP_264676281.1 VRR-NUC domain-containing protein -
LP094_RS06985 (LP094_06945) 1308937..1309215 + 279 WP_264676282.1 hypothetical protein -
LP094_RS06990 (LP094_06950) 1309237..1309527 + 291 WP_112742084.1 hypothetical protein -
LP094_RS06995 (LP094_06955) 1309524..1310009 + 486 WP_078273444.1 recombination protein NinB -
LP094_RS07000 (LP094_06960) 1310146..1310301 + 156 WP_264676283.1 hypothetical protein -
LP094_RS07005 (LP094_06965) 1310298..1310519 + 222 WP_264676284.1 DUF3310 domain-containing protein -
LP094_RS07010 (LP094_06970) 1310503..1310904 + 402 WP_264676285.1 antiterminator Q family protein -
LP094_RS07015 (LP094_06975) 1310915..1311328 - 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP094_RS07020 (LP094_06980) 1311390..1311572 - 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP094_RS07025 (LP094_06985) 1311972..1312676 + 705 WP_264676288.1 BRO family protein -
LP094_RS07030 (LP094_06990) 1313103..1313303 - 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP094_RS07035 (LP094_06995) 1313340..1313549 - 210 WP_264676290.1 hypothetical protein -
LP094_RS07040 (LP094_07000) 1313663..1314202 + 540 WP_264676291.1 terminase small subunit -
LP094_RS07045 (LP094_07005) 1314202..1315599 + 1398 WP_264676292.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1292098..1345756 53658


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226372 WP_264676287.1 NZ_CP087851:c1311572-1311390 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226372 NZ_CP122454:650726-650899 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226372 WP_264676286.1 NZ_CP087851:c1311328-1310915 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226372 NZ_CP122454:650402-650698 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References