Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 638377..639026 Replicon chromosome
Accession NZ_CP087851
Organism Moraxella bovis strain SAM57991

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP094_RS03315 Protein ID WP_078274052.1
Coordinates 638625..639026 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP094_RS03310 Protein ID WP_112741908.1
Coordinates 638377..638610 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP094_RS03290 (LP094_03280) 633773..634222 - 450 WP_264676133.1 cytochrome c -
LP094_RS03295 (LP094_03285) 634404..635396 - 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP094_RS03300 (LP094_03290) 635416..636009 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP094_RS03305 (LP094_03295) 636230..638329 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP094_RS03310 (LP094_03300) 638377..638610 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP094_RS03315 (LP094_03305) 638625..639026 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP094_RS03320 (LP094_03310) 639550..640050 + 501 WP_112741909.1 WG repeat-containing protein -
LP094_RS03325 (LP094_03315) 640172..641002 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP094_RS03330 (LP094_03320) 641101..641790 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP094_RS03340 (LP094_03330) 642526..642945 - 420 WP_078274047.1 S4 domain-containing protein -
LP094_RS03345 (LP094_03335) 642942..643118 - 177 WP_228157829.1 ASCH domain-containing protein -
LP094_RS03350 (LP094_03340) 643137..643370 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226367 WP_078274052.1 NZ_CP087851:638625-639026 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226367 NZ_CP122451:c4988566-4988255 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226367 WP_112741908.1 NZ_CP087851:638377-638610 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226367 NZ_CP122451:c4988254-4987964 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References