Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 477801..478459 | Replicon | chromosome |
| Accession | NZ_CP087851 | ||
| Organism | Moraxella bovis strain SAM57991 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP094_RS02500 | Protein ID | WP_078274940.1 |
| Coordinates | 477801..477989 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP094_RS02505 | Protein ID | WP_112741846.1 |
| Coordinates | 478052..478459 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP094_RS02445 (LP094_02435) | 473202..473621 | - | 420 | WP_112741841.1 | S24 family peptidase | - |
| LP094_RS02450 (LP094_02440) | 473618..473905 | - | 288 | WP_078274962.1 | ORF6C domain-containing protein | - |
| LP094_RS02455 (LP094_02445) | 474100..474399 | - | 300 | WP_078274961.1 | helix-turn-helix transcriptional regulator | - |
| LP094_RS02460 (LP094_02450) | 474564..474773 | + | 210 | WP_078274960.1 | hypothetical protein | - |
| LP094_RS02465 (LP094_02455) | 474788..474979 | + | 192 | WP_264676101.1 | DNA-binding protein | - |
| LP094_RS02470 (LP094_02460) | 474988..475188 | + | 201 | WP_264676324.1 | hypothetical protein | - |
| LP094_RS02475 (LP094_02465) | 475266..476018 | + | 753 | WP_078274945.1 | hypothetical protein | - |
| LP094_RS02480 (LP094_02470) | 476062..476406 | - | 345 | WP_078274944.1 | helix-turn-helix transcriptional regulator | - |
| LP094_RS02485 (LP094_02475) | 476529..476735 | + | 207 | WP_264676102.1 | DNA-binding protein | - |
| LP094_RS02490 (LP094_02480) | 476842..477441 | + | 600 | WP_078274942.1 | antA/AntB antirepressor family protein | - |
| LP094_RS02495 (LP094_02485) | 477443..477658 | + | 216 | WP_078274941.1 | hypothetical protein | - |
| LP094_RS02500 (LP094_02490) | 477801..477989 | + | 189 | WP_078274940.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP094_RS02505 (LP094_02495) | 478052..478459 | + | 408 | WP_112741846.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP094_RS02510 (LP094_02500) | 478535..479506 | + | 972 | WP_112741847.1 | phage tail tape measure protein | - |
| LP094_RS02515 (LP094_02505) | 479503..479835 | + | 333 | WP_112741848.1 | hypothetical protein | - |
| LP094_RS02520 (LP094_02510) | 479769..480206 | + | 438 | WP_162860346.1 | hypothetical protein | - |
| LP094_RS02525 (LP094_02515) | 480260..481066 | + | 807 | WP_112741850.1 | hypothetical protein | - |
| LP094_RS02530 (LP094_02520) | 481067..481411 | + | 345 | WP_078274937.1 | hypothetical protein | - |
| LP094_RS02535 (LP094_02525) | 481399..483228 | + | 1830 | WP_078274936.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 459873..487696 | 27823 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7047.13 Da Isoelectric Point: 10.3659
>T226366 WP_078274940.1 NZ_CP087851:477801-477989 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
Download Length: 189 bp
>T226366 NZ_CP122451:c4690250-4690077 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 136 a.a. Molecular weight: 14756.85 Da Isoelectric Point: 4.2244
>AT226366 WP_112741846.1 NZ_CP087851:478052-478459 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
Download Length: 408 bp
>AT226366 NZ_CP122451:c4690574-4690278 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|