Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2204733..2205391 Replicon chromosome
Accession NZ_CP087848
Organism Moraxella bovis strain SAM57994

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP114_RS11095 Protein ID WP_078274940.1
Coordinates 2205203..2205391 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP114_RS11090 Protein ID WP_112741846.1
Coordinates 2204733..2205140 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP114_RS11060 (LP114_10965) 2199964..2201793 - 1830 WP_078274936.1 hypothetical protein -
LP114_RS11065 (LP114_10970) 2201781..2202125 - 345 WP_078274937.1 hypothetical protein -
LP114_RS11070 (LP114_10975) 2202126..2202932 - 807 WP_264684230.1 hypothetical protein -
LP114_RS11075 (LP114_10980) 2202986..2203423 - 438 WP_162860346.1 hypothetical protein -
LP114_RS11080 (LP114_10985) 2203357..2203689 - 333 WP_112741848.1 hypothetical protein -
LP114_RS11085 (LP114_10990) 2203686..2204657 - 972 WP_112741847.1 phage tail tape measure protein -
LP114_RS11090 (LP114_10995) 2204733..2205140 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP114_RS11095 (LP114_11000) 2205203..2205391 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP114_RS11100 (LP114_11005) 2205534..2205749 - 216 WP_078274941.1 hypothetical protein -
LP114_RS11105 (LP114_11010) 2205751..2206350 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP114_RS11110 (LP114_11015) 2206457..2206663 - 207 WP_264676102.1 DNA-binding protein -
LP114_RS11115 (LP114_11020) 2206786..2207130 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP114_RS11120 (LP114_11025) 2207174..2207926 - 753 WP_078274945.1 hypothetical protein -
LP114_RS11125 (LP114_11030) 2208004..2208204 - 201 WP_264676324.1 hypothetical protein -
LP114_RS11130 (LP114_11035) 2208213..2208404 - 192 WP_264676101.1 DNA-binding protein -
LP114_RS11135 (LP114_11040) 2208419..2208628 - 210 WP_078274960.1 hypothetical protein -
LP114_RS11140 (LP114_11045) 2208793..2209092 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP114_RS11145 (LP114_11050) 2209287..2209574 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP114_RS11150 (LP114_11055) 2209571..2209990 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2199681..2209990 10309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226365 WP_078274940.1 NZ_CP087848:c2205391-2205203 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226365 NZ_CP122451:c4418979-4418602 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226365 WP_112741846.1 NZ_CP087848:c2205140-2204733 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226365 NZ_CP122451:c4419437-4419069 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References