Detailed information of TA system TA226364

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1309277..1309934
• Replicon: chromosome
• Accession: NZ_CP087848
• Organism: Moraxella bovis strain SAM57994

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP114_RS06860
• Protein ID: WP_264676287.1
• Coordinates: 1309752..1309934 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP114_RS06855
• Protein ID: WP_264676286.1
• Coordinates: 1309277..1309690 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP114_RS06810 (LP114_06750)	1304952..1305560	+	609	WP_078273440.1	hypothetical protein	-
LP114_RS06815 (LP114_06755)	1305557..1305964	+	408	WP_112742083.1	VRR-NUC domain-containing protein	-
LP114_RS06820 (LP114_06760)	1305961..1306239	+	279	WP_264682994.1	hypothetical protein	-
LP114_RS06825 (LP114_06765)	1306286..1306483	-	198	WP_264682993.1	ribbon-helix-helix domain-containing protein	-
LP114_RS06830 (LP114_06770)	1307145..1307822	+	678	WP_264682991.1	Bro-N domain-containing protein	-
LP114_RS06835 (LP114_06775)	1307886..1308371	+	486	WP_078273444.1	recombination protein NinB	-
LP114_RS06840 (LP114_06780)	1308508..1308663	+	156	WP_264676283.1	hypothetical protein	-
LP114_RS06845 (LP114_06785)	1308660..1308881	+	222	WP_264676284.1	DUF3310 domain-containing protein	-
LP114_RS06850 (LP114_06790)	1308865..1309266	+	402	WP_264676285.1	antiterminator Q family protein	-
LP114_RS06855 (LP114_06795)	1309277..1309690	-	414	WP_264676286.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP114_RS06860 (LP114_06800)	1309752..1309934	-	183	WP_264676287.1	type II toxin-antitoxin system HicA family toxin	Toxin
LP114_RS06865 (LP114_06805)	1310334..1311038	+	705	WP_264676288.1	BRO family protein	-
LP114_RS06870 (LP114_06810)	1311465..1311665	-	201	WP_264676289.1	helix-turn-helix domain-containing protein	-
LP114_RS06875 (LP114_06815)	1311702..1311911	-	210	WP_264676290.1	hypothetical protein	-
LP114_RS06880 (LP114_06820)	1312025..1312564	+	540	WP_264676291.1	terminase small subunit	-
LP114_RS06885 (LP114_06825)	1312564..1313961	+	1398	WP_264676292.1	phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1289540..1341238	51698

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-79)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6761.81 Da
• Isoelectric Point: 10.7622

>T226364 WP_264676287.1 NZ_CP087848:c1309934-1309752 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Nucleotide

• Length: 183 bp

>T226364 NZ_CP122451:c4244536-4244222 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15339.53 Da
• Isoelectric Point: 4.7523

>AT226364 WP_264676286.1 NZ_CP087848:c1309690-1309277 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Nucleotide

• Length: 414 bp

>AT226364 NZ_CP122451:c4244772-4244539 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG