Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1166003..1166492 Replicon chromosome
Accession NZ_CP087848
Organism Moraxella bovis strain SAM57994

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LP114_RS06145 Protein ID WP_112742208.1
Coordinates 1166235..1166492 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LP114_RS06140 Protein ID WP_228157840.1
Coordinates 1166003..1166245 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP114_RS06100 (LP114_06055) 1161103..1162152 + 1050 WP_112742206.1 RluA family pseudouridine synthase -
LP114_RS06105 (LP114_06060) 1162271..1163068 + 798 WP_112742207.1 polyphenol oxidase family protein -
LP114_RS06110 1163065..1163277 + 213 WP_264676263.1 bestrophin family protein -
LP114_RS06115 (LP114_06065) 1163267..1163785 + 519 WP_264676264.1 bestrophin family protein -
LP114_RS06120 1163945..1164469 + 525 Protein_1190 DUF853 family protein -
LP114_RS06125 1164456..1165247 + 792 WP_264698394.1 DUF853 domain-containing protein -
LP114_RS06130 (LP114_06075) 1165425..1165712 + 288 WP_078273310.1 DUF1315 family protein -
LP114_RS06135 (LP114_06080) 1165794..1165958 - 165 WP_162860378.1 hypothetical protein -
LP114_RS06140 (LP114_06085) 1166003..1166245 + 243 WP_228157840.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LP114_RS06145 (LP114_06090) 1166235..1166492 + 258 WP_112742208.1 Txe/YoeB family addiction module toxin Toxin
LP114_RS06150 (LP114_06095) 1166551..1167060 + 510 WP_112742209.1 peptidylprolyl isomerase -
LP114_RS06155 (LP114_06100) 1167126..1167929 + 804 WP_078273307.1 UDP-2,3-diacylglucosamine diphosphatase -
LP114_RS06160 (LP114_06105) 1168025..1170547 - 2523 WP_264684167.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-68)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10488.99 Da        Isoelectric Point: 7.6652

>T226363 WP_112742208.1 NZ_CP087848:1166235-1166492 [Moraxella bovis]
MRIRWFDEVWEDYLYWQSQDKKTIKRINTLIKDCRRDPFDGIGKPEPLKYNLTGYWLRRIDDANRLVYCCESETLIISCR
HHYEA

Download         Length: 258 bp

>T226363 NZ_CP122451:c4006134-4005736 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9134.23 Da        Isoelectric Point: 6.2120

>AT226363 WP_228157840.1 NZ_CP087848:1166003-1166245 [Moraxella bovis]
MNYSEFRQNLASALDYVQDSHAPVIVKRGKHSAVVISLDEYNAFKETDYLLSNPANAEHLMRGVQAVKNRQLTQRDLIED

Download         Length: 243 bp

>AT226363 NZ_CP122451:c4006430-4006137 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References