Detailed information of TA system TA226362

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 953123..953675
• Replicon: chromosome
• Accession: NZ_CP087848
• Organism: Moraxella bovis strain SAM57994

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP114_RS04935
• Protein ID: WP_029102268.1
• Coordinates: 953397..953675 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP114_RS04930
• Protein ID: WP_078273473.1
• Coordinates: 953123..953410 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP114_RS04910 (LP114_04885)	948558..949607	+	1050	WP_264683526.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP114_RS04915 (LP114_04890)	949686..951185	+	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP114_RS04920	951214..951339	+	126	WP_264676709.1	hypothetical protein	-
LP114_RS04925 (LP114_04895)	951383..953113	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP114_RS04930 (LP114_04900)	953123..953410	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP114_RS04935 (LP114_04905)	953397..953675	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP114_RS04940 (LP114_04910)	953770..954426	-	657	WP_264678114.1	YqiJ family protein	-
LP114_RS04945 (LP114_04915)	954626..955291	-	666	WP_115369658.1	PspA/IM30 family protein	-
LP114_RS04950 (LP114_04920)	955504..955686	-	183	WP_264683628.1	hypothetical protein	-
LP114_RS04955 (LP114_04925)	955787..956302	-	516	WP_264678117.1	hypothetical protein	-
LP114_RS04960 (LP114_04930)	956450..956800	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP114_RS04965 (LP114_04935)	956913..957689	+	777	WP_264678118.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226362 WP_029102268.1 NZ_CP087848:c953675-953397 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226362 NZ_CP122451:3772005-3772223 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226362 WP_078273473.1 NZ_CP087848:c953410-953123 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226362 NZ_CP122451:3771605-3771979 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3