Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 639416..640065 Replicon chromosome
Accession NZ_CP087848
Organism Moraxella bovis strain SAM57994

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP114_RS03200 Protein ID WP_078274052.1
Coordinates 639664..640065 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP114_RS03195 Protein ID WP_112741908.1
Coordinates 639416..639649 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP114_RS03175 (LP114_03155) 634812..635261 - 450 WP_264683685.1 cytochrome c -
LP114_RS03180 (LP114_03160) 635443..636435 - 993 WP_264698351.1 oxygen-dependent coproporphyrinogen oxidase -
LP114_RS03185 (LP114_03165) 636455..637048 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP114_RS03190 (LP114_03170) 637269..639368 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP114_RS03195 (LP114_03175) 639416..639649 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP114_RS03200 (LP114_03180) 639664..640065 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP114_RS03205 (LP114_03185) 640589..641089 + 501 WP_112741909.1 WG repeat-containing protein -
LP114_RS03210 (LP114_03190) 641211..642041 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP114_RS03215 (LP114_03195) 642140..642829 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP114_RS03225 (LP114_03205) 643565..643984 - 420 WP_078274047.1 S4 domain-containing protein -
LP114_RS03230 (LP114_03210) 643981..644130 - 150 WP_162860355.1 hypothetical protein -
LP114_RS03235 (LP114_03215) 644176..644409 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226359 WP_078274052.1 NZ_CP087848:639664-640065 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226359 NZ_CP122451:2548989-2549267 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226359 WP_112741908.1 NZ_CP087848:639416-639649 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226359 NZ_CP122451:2549267-2549551 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References