Detailed information of TA system TA226357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 433519..434077
• Replicon: chromosome
• Accession: NZ_CP087848
• Organism: Moraxella bovis strain SAM57994

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP114_RS02170
• Protein ID: WP_228157760.1
• Coordinates: 433805..434077 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP114_RS02165
• Protein ID: WP_029103533.1
• Coordinates: 433519..433812 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP114_RS02145 (LP114_02130)	429030..430364	-	1335	WP_078275195.1	valine--pyruvate transaminase	-
LP114_RS02150 (LP114_02135)	430484..431095	+	612	WP_112741794.1	methyltransferase	-
LP114_RS02155 (LP114_02140)	431116..431832	+	717	WP_078275193.1	hypothetical protein	-
LP114_RS02160 (LP114_02145)	432041..433375	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP114_RS02165 (LP114_02150)	433519..433812	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP114_RS02170 (LP114_02155)	433805..434077	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP114_RS02175 (LP114_02160)	434335..434724	-	390	WP_264698332.1	type IV secretion protein Rhs	-
LP114_RS02180 (LP114_02165)	434775..435548	+	774	WP_078275191.1	hypothetical protein	-
LP114_RS02185 (LP114_02170)	435527..436786	+	1260	WP_078275190.1	replication-associated recombination protein A	-
LP114_RS02190 (LP114_02175)	436866..437129	+	264	WP_078275189.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LP114_RS02195 (LP114_02180)	437126..437518	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP114_RS02200 (LP114_02185)	437641..438171	+	531	WP_078275187.1	HI_0552 family protein	-
LP114_RS02205 (LP114_02190)	438168..438734	-	567	WP_264684248.1	hypothetical protein	-
LP114_RS02210 (LP114_02195)	438737..438973	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226357 WP_228157760.1 NZ_CP087848:433805-434077 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226357 NZ_CP122451:2209993-2210095 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226357 WP_029103533.1 NZ_CP087848:433519-433812 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226357 NZ_CP122451:c2210133-2209865 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6