Detailed information of TA system TA226354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2317942..2318500
• Replicon: chromosome
• Accession: NZ_CP087844
• Organism: Moraxella bovis strain SAM58105

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP103_RS11875
• Protein ID: WP_228157760.1
• Coordinates: 2317942..2318214 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP103_RS11880
• Protein ID: WP_029103533.1
• Coordinates: 2318207..2318500 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP103_RS11835 (LP103_11725)	2313156..2313392	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP103_RS11840 (LP103_11730)	2313395..2313961	+	567	WP_078275186.1	hypothetical protein	-
LP103_RS11845 (LP103_11735)	2313958..2314488	-	531	WP_078275187.1	HI_0552 family protein	-
LP103_RS11850 (LP103_11740)	2314611..2315003	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP103_RS11855 (LP103_11745)	2315000..2315263	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP103_RS11860 (LP103_11750)	2315343..2316602	-	1260	WP_264675983.1	replication-associated recombination protein A	-
LP103_RS11865 (LP103_11755)	2316960..2317337	-	378	WP_264675984.1	hypothetical protein	-
LP103_RS11870 (LP103_11760)	2317422..2317877	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP103_RS11875 (LP103_11765)	2317942..2318214	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP103_RS11880 (LP103_11770)	2318207..2318500	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP103_RS11885 (LP103_11775)	2318644..2319978	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP103_RS11890 (LP103_11780)	2320187..2320903	-	717	WP_078275193.1	hypothetical protein	-
LP103_RS11895 (LP103_11785)	2320924..2321535	-	612	WP_112741794.1	methyltransferase	-
LP103_RS11900 (LP103_11790)	2321655..2322989	+	1335	WP_078275195.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226354 WP_228157760.1 NZ_CP087844:c2318214-2317942 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226354 NZ_CP122451:1910829-1911080 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226354 WP_029103533.1 NZ_CP087844:c2318500-2318207 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226354 NZ_CP122451:1911077-1911331 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6