Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2314611..2315263 Replicon chromosome
Accession NZ_CP087844
Organism Moraxella bovis strain SAM58105

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP103_RS11850 Protein ID WP_078275188.1
Coordinates 2314611..2315003 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP103_RS11855 Protein ID WP_264675982.1
Coordinates 2315000..2315263 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP103_RS11815 (LP103_11705) 2309703..2310644 + 942 WP_078275181.1 hydroxymethylbilane synthase -
LP103_RS11820 (LP103_11710) 2310690..2311568 + 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP103_RS11825 (LP103_11715) 2311599..2312621 + 1023 WP_078275183.1 hypothetical protein -
LP103_RS11830 (LP103_11720) 2312701..2313159 + 459 WP_078275184.1 acyl-CoA thioesterase -
LP103_RS11835 (LP103_11725) 2313156..2313392 + 237 WP_078275185.1 sulfurtransferase TusA -
LP103_RS11840 (LP103_11730) 2313395..2313961 + 567 WP_078275186.1 hypothetical protein -
LP103_RS11845 (LP103_11735) 2313958..2314488 - 531 WP_078275187.1 HI_0552 family protein -
LP103_RS11850 (LP103_11740) 2314611..2315003 - 393 WP_078275188.1 type II toxin-antitoxin system VapC family toxin Toxin
LP103_RS11855 (LP103_11745) 2315000..2315263 - 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP103_RS11860 (LP103_11750) 2315343..2316602 - 1260 WP_264675983.1 replication-associated recombination protein A -
LP103_RS11865 (LP103_11755) 2316960..2317337 - 378 WP_264675984.1 hypothetical protein -
LP103_RS11870 (LP103_11760) 2317422..2317877 + 456 WP_264675985.1 type IV secretion protein Rhs -
LP103_RS11875 (LP103_11765) 2317942..2318214 - 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP103_RS11880 (LP103_11770) 2318207..2318500 - 294 WP_029103533.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP103_RS11885 (LP103_11775) 2318644..2319978 - 1335 WP_112741795.1 deoxyguanosinetriphosphate triphosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14689.79 Da        Isoelectric Point: 4.7370

>T226353 WP_078275188.1 NZ_CP087844:c2315003-2314611 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226353 NZ_CP122451:1185070-1185381 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226353 WP_264675982.1 NZ_CP087844:c2315263-2315000 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226353 NZ_CP122451:1185378-1185797 [Escherichia coli]
ATGACTGCTAATGCTGTACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References