Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2073118..2073694 Replicon chromosome
Accession NZ_CP087844
Organism Moraxella bovis strain SAM58105

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP103_RS10595 Protein ID WP_264676341.1
Coordinates 2073118..2073378 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP103_RS10600 Protein ID WP_078273964.1
Coordinates 2073359..2073694 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP103_RS10580 (LP103_10495) 2068149..2070224 + 2076 WP_264675941.1 NAD-dependent DNA ligase LigA -
LP103_RS10585 (LP103_10500) 2070737..2072122 + 1386 WP_078273966.1 APC family permease -
LP103_RS10590 (LP103_10505) 2072212..2072919 - 708 WP_264675942.1 ParA family protein -
LP103_RS10595 (LP103_10510) 2073118..2073378 + 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP103_RS10600 (LP103_10515) 2073359..2073694 + 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP103_RS10605 (LP103_10520) 2073878..2074462 - 585 Protein_2077 TetR/AcrR family transcriptional regulator -
LP103_RS10610 (LP103_10525) 2074724..2075905 + 1182 WP_078274027.1 fatty acid desaturase -
LP103_RS10615 (LP103_10530) 2076551..2077318 + 768 WP_112742541.1 carbonic anhydrase family protein -
LP103_RS10620 (LP103_10535) 2077452..2078534 + 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226352 WP_264676341.1 NZ_CP087844:2073118-2073378 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226352 NZ_CP122451:1114573-1114908 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226352 WP_078273964.1 NZ_CP087844:2073359-2073694 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226352 NZ_CP122451:1114325-1114573 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGATCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References