Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1297643..1298300 Replicon chromosome
Accession NZ_CP087844
Organism Moraxella bovis strain SAM58105

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP103_RS06890 Protein ID WP_264676287.1
Coordinates 1298118..1298300 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP103_RS06885 Protein ID WP_264676286.1
Coordinates 1297643..1298056 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP103_RS06840 (LP103_06785) 1293318..1293926 + 609 WP_078273440.1 hypothetical protein -
LP103_RS06845 (LP103_06790) 1293923..1294330 + 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP103_RS06850 (LP103_06795) 1294327..1294605 + 279 WP_264682994.1 hypothetical protein -
LP103_RS06855 (LP103_06800) 1294652..1294849 - 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP103_RS06860 (LP103_06805) 1295511..1296188 + 678 WP_264682991.1 Bro-N domain-containing protein -
LP103_RS06865 (LP103_06810) 1296252..1296737 + 486 WP_078273444.1 recombination protein NinB -
LP103_RS06870 (LP103_06815) 1296874..1297029 + 156 WP_264676283.1 hypothetical protein -
LP103_RS06875 (LP103_06820) 1297026..1297247 + 222 WP_264676284.1 DUF3310 domain-containing protein -
LP103_RS06880 (LP103_06825) 1297231..1297632 + 402 WP_264676285.1 antiterminator Q family protein -
LP103_RS06885 (LP103_06830) 1297643..1298056 - 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP103_RS06890 (LP103_06835) 1298118..1298300 - 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP103_RS06895 (LP103_06840) 1298700..1299404 + 705 WP_264676288.1 BRO family protein -
LP103_RS06900 (LP103_06845) 1299831..1300031 - 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP103_RS06905 (LP103_06850) 1300068..1300277 - 210 WP_264676290.1 hypothetical protein -
LP103_RS06910 (LP103_06855) 1300391..1300930 + 540 WP_264676291.1 terminase small subunit -
LP103_RS06915 (LP103_06860) 1300930..1302327 + 1398 WP_264676292.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1277494..1337889 60395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226351 WP_264676287.1 NZ_CP087844:c1298300-1298118 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226351 NZ_CP122451:940101-940508 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226351 WP_264676286.1 NZ_CP087844:c1298056-1297643 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226351 NZ_CP122451:939854-940120 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References