Detailed information of TA system TA226349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 960470..961022
• Replicon: chromosome
• Accession: NZ_CP087844
• Organism: Moraxella bovis strain SAM58105

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP103_RS05100
• Protein ID: WP_029102268.1
• Coordinates: 960744..961022 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP103_RS05095
• Protein ID: WP_078273473.1
• Coordinates: 960470..960757 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP103_RS05075 (LP103_05050)	955905..956954	+	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP103_RS05080 (LP103_05055)	957033..958532	+	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP103_RS05085	958561..958686	+	126	WP_264676709.1	hypothetical protein	-
LP103_RS05090 (LP103_05060)	958730..960460	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP103_RS05095 (LP103_05065)	960470..960757	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP103_RS05100 (LP103_05070)	960744..961022	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP103_RS05105 (LP103_05075)	961117..961773	-	657	WP_078273472.1	YqiJ family protein	-
LP103_RS05110 (LP103_05080)	961973..962638	-	666	WP_078273471.1	PspA/IM30 family protein	-
LP103_RS05115 (LP103_05085)	962851..963033	-	183	WP_264683628.1	hypothetical protein	-
LP103_RS05120 (LP103_05090)	963134..963649	-	516	WP_115369660.1	hypothetical protein	-
LP103_RS05125 (LP103_05095)	963797..964147	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP103_RS05130 (LP103_05100)	964259..965035	+	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226349 WP_029102268.1 NZ_CP087844:c961022-960744 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226349 NZ_CP122451:c595121-594657 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTCGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226349 WP_078273473.1 NZ_CP087844:c960757-960470 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226349 NZ_CP122451:c595456-595121 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTC
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3