Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 637595..638244 Replicon chromosome
Accession NZ_CP087844
Organism Moraxella bovis strain SAM58105

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP103_RS03295 Protein ID WP_078274052.1
Coordinates 637843..638244 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP103_RS03290 Protein ID WP_112741908.1
Coordinates 637595..637828 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP103_RS03270 (LP103_03255) 632991..633440 - 450 WP_264676133.1 cytochrome c -
LP103_RS03275 (LP103_03260) 633622..634614 - 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP103_RS03280 (LP103_03265) 634634..635227 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP103_RS03285 (LP103_03270) 635448..637547 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP103_RS03290 (LP103_03275) 637595..637828 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP103_RS03295 (LP103_03280) 637843..638244 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP103_RS03300 (LP103_03285) 638768..639268 + 501 WP_112741909.1 WG repeat-containing protein -
LP103_RS03305 (LP103_03290) 639390..640220 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP103_RS03310 (LP103_03295) 640319..641008 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP103_RS03320 (LP103_03305) 641744..642163 - 420 WP_078274047.1 S4 domain-containing protein -
LP103_RS03325 (LP103_03310) 642160..642336 - 177 WP_228157829.1 ASCH domain-containing protein -
LP103_RS03330 (LP103_03315) 642355..642588 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226346 WP_078274052.1 NZ_CP087844:637843-638244 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226346 NZ_CP122450:4190-4465 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTACTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTATGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226346 WP_112741908.1 NZ_CP087844:637595-637828 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226346 NZ_CP122450:3906-4190 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAACAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAATCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCAGACAGCCTCAATACTGACAATCCGTTACCGGTGCCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References