Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 477168..477826 Replicon chromosome
Accession NZ_CP087844
Organism Moraxella bovis strain SAM58105

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP103_RS02500 Protein ID WP_078274940.1
Coordinates 477168..477356 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP103_RS02505 Protein ID WP_112741846.1
Coordinates 477419..477826 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP103_RS02445 (LP103_02430) 472569..472988 - 420 WP_112741841.1 S24 family peptidase -
LP103_RS02450 (LP103_02435) 472985..473272 - 288 WP_078274962.1 ORF6C domain-containing protein -
LP103_RS02455 (LP103_02440) 473467..473766 - 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP103_RS02460 (LP103_02445) 473931..474140 + 210 WP_078274960.1 hypothetical protein -
LP103_RS02465 (LP103_02450) 474155..474346 + 192 WP_264676101.1 DNA-binding protein -
LP103_RS02470 (LP103_02455) 474355..474555 + 201 WP_264676324.1 hypothetical protein -
LP103_RS02475 (LP103_02460) 474633..475385 + 753 WP_078274945.1 hypothetical protein -
LP103_RS02480 (LP103_02465) 475429..475773 - 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP103_RS02485 (LP103_02470) 475896..476102 + 207 WP_264676102.1 DNA-binding protein -
LP103_RS02490 (LP103_02475) 476209..476808 + 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP103_RS02495 (LP103_02480) 476810..477025 + 216 WP_078274941.1 hypothetical protein -
LP103_RS02500 (LP103_02485) 477168..477356 + 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP103_RS02505 (LP103_02490) 477419..477826 + 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP103_RS02510 (LP103_02495) 477902..478873 + 972 WP_112741847.1 phage tail tape measure protein -
LP103_RS02515 (LP103_02500) 478870..479202 + 333 WP_112741848.1 hypothetical protein -
LP103_RS02520 (LP103_02505) 479136..479573 + 438 WP_162860346.1 hypothetical protein -
LP103_RS02525 (LP103_02510) 479627..480433 + 807 WP_112741850.1 hypothetical protein -
LP103_RS02530 (LP103_02515) 480434..480778 + 345 WP_078274937.1 hypothetical protein -
LP103_RS02535 (LP103_02520) 480766..482595 + 1830 WP_078274936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 459241..487063 27822


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226345 WP_078274940.1 NZ_CP087844:477168-477356 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226345 NZ_CP122449:50467-50772 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226345 WP_112741846.1 NZ_CP087844:477419-477826 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226345 NZ_CP122449:50247-50465 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References