Detailed information of TA system TA226344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2822855..2823413
• Replicon: chromosome
• Accession: NZ_CP087843
• Organism: Moraxella bovis strain SAM58106

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP121_RS14390
• Protein ID: WP_228157760.1
• Coordinates: 2822855..2823127 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP121_RS14395
• Protein ID: WP_029103533.1
• Coordinates: 2823120..2823413 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP121_RS14350 (LP121_14230)	2818101..2818337	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP121_RS14355 (LP121_14235)	2818340..2818906	+	567	WP_264684248.1	hypothetical protein	-
LP121_RS14360 (LP121_14240)	2818903..2819433	-	531	WP_078275187.1	HI_0552 family protein	-
LP121_RS14365 (LP121_14245)	2819556..2819948	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP121_RS14370 (LP121_14250)	2819945..2820208	-	264	WP_078275189.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LP121_RS14375 (LP121_14255)	2820288..2821547	-	1260	WP_078275190.1	replication-associated recombination protein A	-
LP121_RS14380 (LP121_14260)	2821526..2822299	-	774	WP_078275191.1	hypothetical protein	-
LP121_RS14385 (LP121_14265)	2822350..2822790	+	441	WP_208624064.1	type IV secretion protein Rhs	-
LP121_RS14390 (LP121_14270)	2822855..2823127	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP121_RS14395 (LP121_14275)	2823120..2823413	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP121_RS14400 (LP121_14280)	2823557..2824891	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP121_RS14405 (LP121_14285)	2825100..2825816	-	717	WP_078275193.1	hypothetical protein	-
LP121_RS14410 (LP121_14290)	2825837..2826448	-	612	WP_112741794.1	methyltransferase	-
LP121_RS14415 (LP121_14295)	2826569..2827873	+	1305	WP_264677332.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226344 WP_228157760.1 NZ_CP087843:c2823127-2822855 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226344 NZ_CP122448:c4903875-4903564 [Escherichia coli]
ATCCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226344 WP_029103533.1 NZ_CP087843:c2823413-2823120 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226344 NZ_CP122448:c4903563-4903273 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6