Detailed information of TA system TA226343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2819556..2820208
• Replicon: chromosome
• Accession: NZ_CP087843
• Organism: Moraxella bovis strain SAM58106

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP121_RS14365
• Protein ID: WP_078275188.1
• Coordinates: 2819556..2819948 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP121_RS14370
• Protein ID: WP_078275189.1
• Coordinates: 2819945..2820208 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP121_RS14330 (LP121_14210)	2814648..2815589	+	942	WP_078275181.1	hydroxymethylbilane synthase	-
LP121_RS14335 (LP121_14215)	2815635..2816513	+	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP121_RS14340 (LP121_14220)	2816544..2817566	+	1023	WP_078275183.1	hypothetical protein	-
LP121_RS14345 (LP121_14225)	2817646..2818104	+	459	WP_078275184.1	acyl-CoA thioesterase	-
LP121_RS14350 (LP121_14230)	2818101..2818337	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP121_RS14355 (LP121_14235)	2818340..2818906	+	567	WP_264684248.1	hypothetical protein	-
LP121_RS14360 (LP121_14240)	2818903..2819433	-	531	WP_078275187.1	HI_0552 family protein	-
LP121_RS14365 (LP121_14245)	2819556..2819948	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP121_RS14370 (LP121_14250)	2819945..2820208	-	264	WP_078275189.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LP121_RS14375 (LP121_14255)	2820288..2821547	-	1260	WP_078275190.1	replication-associated recombination protein A	-
LP121_RS14380 (LP121_14260)	2821526..2822299	-	774	WP_078275191.1	hypothetical protein	-
LP121_RS14385 (LP121_14265)	2822350..2822790	+	441	WP_208624064.1	type IV secretion protein Rhs	-
LP121_RS14390 (LP121_14270)	2822855..2823127	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP121_RS14395 (LP121_14275)	2823120..2823413	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP121_RS14400 (LP121_14280)	2823557..2824891	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226343 WP_078275188.1 NZ_CP087843:c2819948-2819556 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226343 NZ_CP122448:c4602528-4602355 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10183.52 Da
• Isoelectric Point: 6.3724

>AT226343 WP_078275189.1 NZ_CP087843:c2820208-2819945 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKTFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226343 NZ_CP122448:c4602852-4602556 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG