Detailed information of TA system TA226342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2549344..2549993
• Replicon: chromosome
• Accession: NZ_CP087843
• Organism: Moraxella bovis strain SAM58106

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP121_RS12955
• Protein ID: WP_078274052.1
• Coordinates: 2549344..2549745 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP121_RS12960
• Protein ID: WP_112741908.1
• Coordinates: 2549760..2549993 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP121_RS12920 (LP121_12810)	2545000..2545233	+	234	WP_112741910.1	ASCH domain-containing protein	-
LP121_RS12925 (LP121_12815)	2545252..2545428	+	177	WP_228157829.1	ASCH domain-containing protein	-
LP121_RS12930 (LP121_12820)	2545425..2545844	+	420	WP_078274047.1	S4 domain-containing protein	-
LP121_RS12940 (LP121_12830)	2546580..2547269	+	690	WP_078274049.1	SIMPL domain-containing protein	-
LP121_RS12945 (LP121_12835)	2547368..2548198	-	831	WP_078274050.1	inositol monophosphatase family protein	-
LP121_RS12950 (LP121_12840)	2548320..2548820	-	501	WP_112741909.1	WG repeat-containing protein	-
LP121_RS12955 (LP121_12845)	2549344..2549745	-	402	WP_078274052.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP121_RS12960 (LP121_12850)	2549760..2549993	-	234	WP_112741908.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP121_RS12965 (LP121_12855)	2550041..2552140	-	2100	WP_078274054.1	1-deoxy-D-xylulose-5-phosphate synthase	-
LP121_RS12970 (LP121_12860)	2552361..2552954	+	594	WP_208624078.1	GTP cyclohydrolase II	-
LP121_RS12975 (LP121_12865)	2552974..2553966	+	993	WP_264684213.1	oxygen-dependent coproporphyrinogen oxidase	-
LP121_RS12980 (LP121_12870)	2554148..2554597	+	450	WP_264676133.1	cytochrome c	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (8-54)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15131.33 Da
• Isoelectric Point: 6.8510

>T226342 WP_078274052.1 NZ_CP087843:c2549745-2549344 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Nucleotide

• Length: 402 bp

>T226342 NZ_CP122448:c4333122-4332745 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8990.22 Da
• Isoelectric Point: 6.2884

>AT226342 WP_112741908.1 NZ_CP087843:c2549993-2549760 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Nucleotide

• Length: 234 bp

>AT226342 NZ_CP122448:c4333580-4333212 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA