Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 986482..987110 Replicon chromosome
Accession NC_010320
Organism Thermoanaerobacter sp. X514

Toxin (Protein)


Gene name mazF Uniprot ID B0KD57
Locus tag TETH514_RS04940 Protein ID WP_003867472.1
Coordinates 986760..987110 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B0KD56
Locus tag TETH514_RS04935 Protein ID WP_003867471.1
Coordinates 986482..986757 (+) Length 92 a.a.

Genomic Context

TETH514_RS04910TETH514_RS04915TETH514_RS04920TETH514_RS04925TETH514_RS04930TETH514_RS04935TETH514_RS04940TETH514_RS04945TETH514_RS04950TETH514_RS04955TETH514_RS04965TETH514_RS04960
Location: 981810..982175 (366 bp)
Type: Others
Protein ID: WP_003867466.1
Location: 982271..982687 (417 bp)
Type: Others
Protein ID: WP_003867467.1
Location: 982650..984182 (1533 bp)
Type: Others
Protein ID: WP_009052807.1
Location: 984194..985204 (1011 bp)
Type: Others
Protein ID: WP_003867469.1
Location: 985226..986392 (1167 bp)
Type: Others
Protein ID: WP_003867470.1
Location: 986482..986757 (276 bp)
Type: Antitoxin
Protein ID: WP_003867471.1
Location: 986760..987110 (351 bp)
Type: Toxin
Protein ID: WP_003867472.1
Location: 987438..988283 (846 bp)
Type: Others
Protein ID: WP_003867473.1
Location: 988299..989120 (822 bp)
Type: Others
Protein ID: WP_012268649.1
Location: 989121..990041 (921 bp)
Type: Others
Protein ID: WP_003870015.1
Location: 990769..992013 (1245 bp)
Type: Others
Protein ID: WP_009052805.1
Location: 990070..990585 (516 bp)
Type: Others
Protein ID: WP_003871225.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
TETH514_RS04910981810..982175+366WP_003867466.1hypothetical protein-
TETH514_RS04915982271..982687+417WP_003867467.1holo-ACP synthase-
TETH514_RS04920982650..984182+1533WP_009052807.1bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase-
TETH514_RS04925984194..985204+1011WP_003867469.1outer membrane lipoprotein carrier protein LolA-
TETH514_RS04930985226..986392+1167WP_003867470.1alanine racemase-
TETH514_RS04935986482..986757+276WP_003867471.1ribbon-helix-helix protein, CopG familyAntitoxin
TETH514_RS04940986760..987110+351WP_003867472.1type II toxin-antitoxin system PemK/MazF family toxinToxin
TETH514_RS04945987438..988283+846WP_003867473.1YitT family protein-
TETH514_RS04950988299..989120+822WP_012268649.1transketolase-
TETH514_RS04955989121..990041+921WP_003870015.1transketolase family protein-
TETH514_RS04960990070..990585-516WP_003871225.1hypothetical protein-
TETH514_RS04965990769..992013+1245WP_009052805.16-phosphofructokinase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12933.02 Da        Isoelectric Point: 6.4714

>T22634 WP_003867472.1 NC_010320:986760-987110 [Thermoanaerobacter sp. X514]
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEINGAEYGLNKDSVVLLEQI
RTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF

Download         Length: 351 bp

>T22634 NC_010320:986760-987110 [Thermoanaerobacter sp. X514]
ATGGTGATAAAGAGGGGAGACATTTTTTATGCCGATTTAAGCCCTGTAATAGGCTCTGAACAGGGCGGAATTCGGCCTGT
ACTTATAATTCAAAATGATATTGGTAATAAATATAGTCCAACAGTAATAGTAGCGGCAATTACATCTCAGATTAACAAAG
CCAAATTGCCCACTCATGTTGAAATAAATGGGGCAGAATATGGACTTAACAAAGATTCTGTAGTATTATTGGAGCAAATA
AGGACTATTGACAAAAAACGTTTAAGAGAAAAAATTGGTCATTTTGACCAGGAAATGATGGAGAAAGTCAATGAAGCTTT
GCAAATAAGTTTAGGGTTGATTGATTTTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10533.33 Da        Isoelectric Point: 6.3661

>AT22634 WP_003867471.1 NC_010320:986482-986757 [Thermoanaerobacter sp. X514]
VGETKRILVSLPQSLLEEVDVLAAMENRNRSEFIREAMKLYIREKKKIQIRESMKKGYLEMAAINSELAEMGLTAENECF
TGYEMKLKKCD

Download         Length: 276 bp

>AT22634 NC_010320:986482-986757 [Thermoanaerobacter sp. X514]
GTGGGCGAAACAAAGCGAATACTTGTAAGCTTGCCGCAAAGTTTATTAGAAGAAGTTGATGTTCTTGCCGCTATGGAAAA
CAGGAATCGCAGTGAATTTATAAGAGAAGCGATGAAATTATATATACGCGAGAAGAAAAAAATTCAAATACGAGAGAGCA
TGAAAAAGGGATATCTTGAGATGGCAGCAATTAACAGTGAACTTGCGGAAATGGGCCTAACCGCAGAAAACGAATGTTTT
ACAGGATATGAAATGAAATTGAAAAAGTGTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0B3BRL3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1M4W2H3

References