Detailed information of TA system TA226339

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 2224247..2224799
• Replicon: chromosome
• Accession: NZ_CP087843
• Organism: Moraxella bovis strain SAM58106

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP121_RS11135
• Protein ID: WP_029102268.1
• Coordinates: 2224247..2224525 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP121_RS11140
• Protein ID: WP_078273473.1
• Coordinates: 2224512..2224799 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP121_RS11105 (LP121_11010)	2220234..2221010	-	777	WP_078273467.1	nucleotidyltransferase domain-containing protein	-
LP121_RS11110 (LP121_11015)	2221122..2221472	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP121_RS11115 (LP121_11020)	2221620..2222135	+	516	WP_078273469.1	hypothetical protein	-
LP121_RS11120 (LP121_11025)	2222209..2222418	+	210	WP_264678116.1	hypothetical protein	-
LP121_RS11125 (LP121_11030)	2222631..2223296	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP121_RS11130 (LP121_11035)	2223496..2224152	+	657	WP_078273472.1	YqiJ family protein	-
LP121_RS11135 (LP121_11040)	2224247..2224525	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP121_RS11140 (LP121_11045)	2224512..2224799	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP121_RS11145 (LP121_11050)	2224809..2226539	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP121_RS11150	2226583..2226708	-	126	WP_264676709.1	hypothetical protein	-
LP121_RS11155 (LP121_11055)	2226737..2228236	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP121_RS11160 (LP121_11060)	2228315..2229364	-	1050	WP_264683526.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226339 WP_029102268.1 NZ_CP087843:2224247-2224525 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226339 NZ_CP122448:c4132751-4132437 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226339 WP_078273473.1 NZ_CP087843:2224512-2224799 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226339 NZ_CP122448:c4132987-4132754 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3