Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1867873..1868530 Replicon chromosome
Accession NZ_CP087843
Organism Moraxella bovis strain SAM58106

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP121_RS09195 Protein ID WP_264676287.1
Coordinates 1867873..1868055 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP121_RS09200 Protein ID WP_264676286.1
Coordinates 1868117..1868530 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP121_RS09170 (LP121_09090) 1863846..1865243 - 1398 WP_264676292.1 phage terminase large subunit -
LP121_RS09175 (LP121_09095) 1865243..1865782 - 540 WP_264676291.1 terminase small subunit -
LP121_RS09180 (LP121_09100) 1865896..1866105 + 210 WP_264676290.1 hypothetical protein -
LP121_RS09185 (LP121_09105) 1866142..1866342 + 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP121_RS09190 (LP121_09110) 1866769..1867473 - 705 WP_264676288.1 BRO family protein -
LP121_RS09195 (LP121_09115) 1867873..1868055 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP121_RS09200 (LP121_09120) 1868117..1868530 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP121_RS09205 (LP121_09125) 1868541..1868942 - 402 WP_264676285.1 antiterminator Q family protein -
LP121_RS09210 (LP121_09130) 1868926..1869147 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP121_RS09215 (LP121_09135) 1869144..1869299 - 156 WP_264676283.1 hypothetical protein -
LP121_RS09220 (LP121_09140) 1869436..1869921 - 486 WP_078273444.1 recombination protein NinB -
LP121_RS09225 (LP121_09145) 1869985..1870662 - 678 WP_264682991.1 Bro-N domain-containing protein -
LP121_RS09230 (LP121_09150) 1871324..1871521 + 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP121_RS09235 (LP121_09155) 1871568..1871846 - 279 WP_264684155.1 hypothetical protein -
LP121_RS09240 (LP121_09160) 1871843..1872250 - 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP121_RS09245 (LP121_09165) 1872247..1872855 - 609 WP_078273440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1834725..1888287 53562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226337 WP_264676287.1 NZ_CP087843:1867873-1868055 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226337 NZ_CP122448:c3818338-3817961 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCTGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCGGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226337 WP_264676286.1 NZ_CP087843:1868117-1868530 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226337 NZ_CP122448:c3818796-3818428 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References