Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 973466..974124 Replicon chromosome
Accession NZ_CP087843
Organism Moraxella bovis strain SAM58106

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP121_RS04940 Protein ID WP_078274940.1
Coordinates 973466..973654 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP121_RS04945 Protein ID WP_112741846.1
Coordinates 973717..974124 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP121_RS04885 (LP121_04845) 968867..969286 - 420 WP_112741841.1 S24 family peptidase -
LP121_RS04890 (LP121_04850) 969283..969570 - 288 WP_078274962.1 ORF6C domain-containing protein -
LP121_RS04895 (LP121_04855) 969765..970064 - 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP121_RS04900 (LP121_04860) 970229..970438 + 210 WP_078274960.1 hypothetical protein -
LP121_RS04905 (LP121_04865) 970453..970644 + 192 WP_264676101.1 DNA-binding protein -
LP121_RS04910 (LP121_04870) 970653..970853 + 201 WP_264676324.1 hypothetical protein -
LP121_RS04915 (LP121_04875) 970931..971683 + 753 WP_078274945.1 hypothetical protein -
LP121_RS04920 (LP121_04880) 971727..972071 - 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP121_RS04925 (LP121_04885) 972194..972400 + 207 WP_264676102.1 DNA-binding protein -
LP121_RS04930 (LP121_04890) 972507..973106 + 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP121_RS04935 (LP121_04895) 973108..973323 + 216 WP_078274941.1 hypothetical protein -
LP121_RS04940 (LP121_04900) 973466..973654 + 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP121_RS04945 (LP121_04905) 973717..974124 + 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP121_RS04950 (LP121_04910) 974200..975171 + 972 WP_112741847.1 phage tail tape measure protein -
LP121_RS04955 (LP121_04915) 975168..975500 + 333 WP_112741848.1 hypothetical protein -
LP121_RS04960 (LP121_04920) 975434..975871 + 438 WP_162860346.1 hypothetical protein -
LP121_RS04965 (LP121_04925) 975925..976731 + 807 WP_264684230.1 hypothetical protein -
LP121_RS04970 (LP121_04930) 976732..977076 + 345 WP_078274937.1 hypothetical protein -
LP121_RS04975 (LP121_04935) 977064..978893 + 1830 WP_078274936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 968867..979176 10309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226336 WP_078274940.1 NZ_CP087843:973466-973654 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226336 NZ_CP122448:3629729-3629947 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226336 WP_112741846.1 NZ_CP087843:973717-974124 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226336 NZ_CP122448:3629329-3629703 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References