Detailed information of TA system TA226334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2250412..2251070
• Replicon: chromosome
• Accession: NZ_CP087840
• Organism: Moraxella bovis strain SAM58116

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP107_RS11455
• Protein ID: WP_078274940.1
• Coordinates: 2250882..2251070 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP107_RS11450
• Protein ID: WP_112741846.1
• Coordinates: 2250412..2250819 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP107_RS11420 (LP107_11315)	2245643..2247472	-	1830	WP_078274936.1	hypothetical protein	-
LP107_RS11425 (LP107_11320)	2247460..2247804	-	345	WP_078274937.1	hypothetical protein	-
LP107_RS11430 (LP107_11325)	2247805..2248611	-	807	WP_112741850.1	hypothetical protein	-
LP107_RS11435 (LP107_11330)	2248665..2249102	-	438	WP_162860346.1	hypothetical protein	-
LP107_RS11440 (LP107_11335)	2249036..2249368	-	333	WP_112741848.1	hypothetical protein	-
LP107_RS11445 (LP107_11340)	2249365..2250336	-	972	WP_112741847.1	phage tail tape measure protein	-
LP107_RS11450 (LP107_11345)	2250412..2250819	-	408	WP_112741846.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP107_RS11455 (LP107_11350)	2250882..2251070	-	189	WP_078274940.1	type II toxin-antitoxin system HicA family toxin	Toxin
LP107_RS11460 (LP107_11355)	2251213..2251428	-	216	WP_078274941.1	hypothetical protein	-
LP107_RS11465 (LP107_11360)	2251430..2252029	-	600	WP_078274942.1	antA/AntB antirepressor family protein	-
LP107_RS11470 (LP107_11365)	2252136..2252342	-	207	WP_264676102.1	DNA-binding protein	-
LP107_RS11475 (LP107_11370)	2252465..2252809	+	345	WP_078274944.1	helix-turn-helix transcriptional regulator	-
LP107_RS11480 (LP107_11375)	2252853..2253605	-	753	WP_078274945.1	hypothetical protein	-
LP107_RS11485 (LP107_11380)	2253683..2253883	-	201	WP_264676324.1	hypothetical protein	-
LP107_RS11490 (LP107_11385)	2253892..2254083	-	192	WP_264676101.1	DNA-binding protein	-
LP107_RS11495 (LP107_11390)	2254098..2254307	-	210	WP_078274960.1	hypothetical protein	-
LP107_RS11500 (LP107_11395)	2254472..2254771	+	300	WP_078274961.1	helix-turn-helix transcriptional regulator	-
LP107_RS11505 (LP107_11400)	2254966..2255253	+	288	WP_078274962.1	ORF6C domain-containing protein	-
LP107_RS11510 (LP107_11405)	2255250..2255669	+	420	WP_112741841.1	S24 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2241175..2255669	14494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7047.13 Da
• Isoelectric Point: 10.3659

>T226334 WP_078274940.1 NZ_CP087840:c2251070-2250882 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Nucleotide

• Length: 189 bp

>T226334 NZ_CP122448:2874999-2875106 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14756.85 Da
• Isoelectric Point: 4.2244

>AT226334 WP_112741846.1 NZ_CP087840:c2250819-2250412 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Nucleotide

• Length: 408 bp

>AT226334 NZ_CP122448:c2874946-2874885 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT