Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2089995..2090644 Replicon chromosome
Accession NZ_CP087840
Organism Moraxella bovis strain SAM58116

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP107_RS10650 Protein ID WP_078274052.1
Coordinates 2089995..2090396 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP107_RS10655 Protein ID WP_112741908.1
Coordinates 2090411..2090644 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP107_RS10615 (LP107_10510) 2085651..2085884 + 234 WP_112741910.1 ASCH domain-containing protein -
LP107_RS10620 (LP107_10515) 2085930..2086079 + 150 WP_162860355.1 hypothetical protein -
LP107_RS10625 (LP107_10520) 2086076..2086495 + 420 WP_078274047.1 S4 domain-containing protein -
LP107_RS10635 (LP107_10530) 2087231..2087920 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP107_RS10640 (LP107_10535) 2088019..2088849 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP107_RS10645 (LP107_10540) 2088971..2089471 - 501 WP_112741909.1 WG repeat-containing protein -
LP107_RS10650 (LP107_10545) 2089995..2090396 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP107_RS10655 (LP107_10550) 2090411..2090644 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP107_RS10660 (LP107_10555) 2090692..2092791 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP107_RS10665 (LP107_10560) 2093012..2093605 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP107_RS10670 (LP107_10565) 2093625..2094617 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP107_RS10675 (LP107_10570) 2094799..2095248 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226333 WP_078274052.1 NZ_CP087840:c2090396-2089995 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226333 NZ_CP122448:2644505-2644783 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226333 WP_112741908.1 NZ_CP087840:c2090644-2090411 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226333 NZ_CP122448:2644783-2645067 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References