Detailed information of TA system TA226330

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1770755..1771307
• Replicon: chromosome
• Accession: NZ_CP087840
• Organism: Moraxella bovis strain SAM58116

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP107_RS08835
• Protein ID: WP_029102268.1
• Coordinates: 1770755..1771033 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP107_RS08840
• Protein ID: WP_078273473.1
• Coordinates: 1771020..1771307 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP107_RS08805 (LP107_08720)	1766742..1767518	-	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-
LP107_RS08810 (LP107_08725)	1767630..1767980	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP107_RS08815 (LP107_08730)	1768128..1768643	+	516	WP_115369660.1	hypothetical protein	-
LP107_RS08820 (LP107_08735)	1768636..1768926	+	291	WP_264676229.1	hypothetical protein	-
LP107_RS08825 (LP107_08740)	1769139..1769804	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP107_RS08830 (LP107_08745)	1770004..1770660	+	657	WP_078273472.1	YqiJ family protein	-
LP107_RS08835 (LP107_08750)	1770755..1771033	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP107_RS08840 (LP107_08755)	1771020..1771307	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP107_RS08845 (LP107_08760)	1771317..1773047	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP107_RS08850	1773091..1773216	-	126	WP_264676709.1	hypothetical protein	-
LP107_RS08855 (LP107_08765)	1773245..1774744	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP107_RS08860 (LP107_08770)	1774823..1775872	-	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226330 WP_029102268.1 NZ_CP087840:1770755-1771033 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226330 NZ_CP122448:c2019987-2019613 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226330 WP_078273473.1 NZ_CP087840:1771020-1771307 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226330 NZ_CP122448:c2020444-2020076 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3