Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 1425444..1426101 | Replicon | chromosome |
| Accession | NZ_CP087840 | ||
| Organism | Moraxella bovis strain SAM58116 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP107_RS06965 | Protein ID | WP_264676287.1 |
| Coordinates | 1425444..1425626 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP107_RS06970 | Protein ID | WP_264676286.1 |
| Coordinates | 1425688..1426101 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP107_RS06940 (LP107_06870) | 1421417..1422814 | - | 1398 | WP_264682745.1 | phage terminase large subunit | - |
| LP107_RS06945 (LP107_06875) | 1422814..1423353 | - | 540 | WP_264676291.1 | terminase small subunit | - |
| LP107_RS06950 (LP107_06880) | 1423467..1423676 | + | 210 | WP_264676290.1 | hypothetical protein | - |
| LP107_RS06955 (LP107_06885) | 1423713..1423913 | + | 201 | WP_264676289.1 | helix-turn-helix domain-containing protein | - |
| LP107_RS06960 (LP107_06890) | 1424340..1425044 | - | 705 | WP_264676288.1 | BRO family protein | - |
| LP107_RS06965 (LP107_06895) | 1425444..1425626 | + | 183 | WP_264676287.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP107_RS06970 (LP107_06900) | 1425688..1426101 | + | 414 | WP_264676286.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP107_RS06975 (LP107_06905) | 1426112..1426513 | - | 402 | WP_264676285.1 | antiterminator Q family protein | - |
| LP107_RS06980 (LP107_06910) | 1426497..1426718 | - | 222 | WP_264676284.1 | DUF3310 domain-containing protein | - |
| LP107_RS06985 (LP107_06915) | 1426715..1426870 | - | 156 | WP_264676283.1 | hypothetical protein | - |
| LP107_RS06990 (LP107_06920) | 1427007..1427492 | - | 486 | WP_078273444.1 | recombination protein NinB | - |
| LP107_RS06995 (LP107_06925) | 1427489..1427779 | - | 291 | WP_112742084.1 | hypothetical protein | - |
| LP107_RS07000 (LP107_06930) | 1427801..1428079 | - | 279 | WP_264676282.1 | hypothetical protein | - |
| LP107_RS07005 (LP107_06935) | 1428076..1428471 | - | 396 | WP_264682746.1 | VRR-NUC domain-containing protein | - |
| LP107_RS07010 (LP107_06940) | 1428468..1429076 | - | 609 | WP_264676191.1 | hypothetical protein | - |
| LP107_RS07015 (LP107_06945) | 1429069..1429959 | - | 891 | WP_264676778.1 | replication protein | - |
| LP107_RS07020 (LP107_06950) | 1429956..1430639 | - | 684 | WP_264676189.1 | Rha family transcriptional regulator | - |
| LP107_RS07025 (LP107_06955) | 1430707..1430982 | - | 276 | WP_112742261.1 | YdaS family helix-turn-helix protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1405383..1444544 | 39161 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6761.81 Da Isoelectric Point: 10.7622
>T226328 WP_264676287.1 NZ_CP087840:1425444-1425626 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL
Download Length: 183 bp
>T226328 NZ_CP122448:2009290-2009541 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15339.53 Da Isoelectric Point: 4.7523
>AT226328 WP_264676286.1 NZ_CP087840:1425688-1426101 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI
Download Length: 414 bp
>AT226328 NZ_CP122448:2009538-2009792 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|