Detailed information of TA system TA226327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 677341..677884
• Replicon: chromosome
• Accession: NZ_CP087840
• Organism: Moraxella bovis strain SAM58116

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP107_RS03470
• Protein ID: WP_245952240.1
• Coordinates: 677657..677884 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP107_RS03465
• Protein ID: WP_078273964.1
• Coordinates: 677341..677676 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP107_RS03445 (LP107_03415)	672501..673583	-	1083	WP_078273961.1	tRNA pseudouridine(13) synthase TruD	-
LP107_RS03450 (LP107_03420)	673717..674484	-	768	WP_112742541.1	carbonic anhydrase family protein	-
LP107_RS03455 (LP107_03425)	675130..676311	-	1182	WP_078274027.1	fatty acid desaturase	-
LP107_RS03460 (LP107_03430)	676573..677157	+	585	Protein_666	TetR/AcrR family transcriptional regulator	-
LP107_RS03465 (LP107_03435)	677341..677676	-	336	WP_078273964.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP107_RS03470 (LP107_03440)	677657..677884	-	228	WP_245952240.1	hypothetical protein	Toxin
LP107_RS03475 (LP107_03445)	678116..678823	+	708	WP_264675942.1	ParA family protein	-
LP107_RS03480 (LP107_03450)	678913..680298	-	1386	WP_078273966.1	APC family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8451.18 Da
• Isoelectric Point: 4.5519

>T226327 WP_245952240.1 NZ_CP087840:c677884-677657 [Moraxella bovis]
ISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQTHEHNDN

Nucleotide

• Length: 228 bp

>T226327 NZ_CP122448:1148825-1149160 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12189.67 Da
• Isoelectric Point: 4.5658

>AT226327 WP_078273964.1 NZ_CP087840:c677676-677341 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Nucleotide

• Length: 336 bp

>AT226327 NZ_CP122448:1148577-1148825 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA