Detailed information of TA system TA226326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 438138..438790
• Replicon: chromosome
• Accession: NZ_CP087840
• Organism: Moraxella bovis strain SAM58116

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP107_RS02215
• Protein ID: WP_078275188.1
• Coordinates: 438398..438790 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP107_RS02210
• Protein ID: WP_264675982.1
• Coordinates: 438138..438401 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP107_RS02180 (LP107_02170)	433423..434757	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP107_RS02185 (LP107_02175)	434901..435194	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP107_RS02190 (LP107_02180)	435187..435459	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP107_RS02195 (LP107_02185)	435524..435979	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP107_RS02200 (LP107_02190)	436064..436441	+	378	WP_264675984.1	hypothetical protein	-
LP107_RS02205 (LP107_02195)	436799..438058	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP107_RS02210 (LP107_02200)	438138..438401	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP107_RS02215 (LP107_02205)	438398..438790	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP107_RS02220 (LP107_02210)	438913..439443	+	531	WP_078275187.1	HI_0552 family protein	-
LP107_RS02225 (LP107_02215)	439440..440006	-	567	WP_078275186.1	hypothetical protein	-
LP107_RS02230 (LP107_02220)	440009..440245	-	237	WP_078275185.1	sulfurtransferase TusA	-
LP107_RS02235 (LP107_02225)	440242..440700	-	459	WP_078275184.1	acyl-CoA thioesterase	-
LP107_RS02240 (LP107_02230)	440780..441802	-	1023	WP_078275183.1	hypothetical protein	-
LP107_RS02245 (LP107_02235)	441833..442711	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP107_RS02250 (LP107_02240)	442757..443698	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226326 WP_078275188.1 NZ_CP087840:438398-438790 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226326 NZ_CP122448:993622-994029 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226326 WP_264675982.1 NZ_CP087840:438138-438401 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226326 NZ_CP122448:993375-993641 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA