Detailed information of TA system TA226323

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2240339..2240997
• Replicon: chromosome
• Accession: NZ_CP087837
• Organism: Moraxella bovis strain SAM68509

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP086_RS11380
• Protein ID: WP_078274940.1
• Coordinates: 2240809..2240997 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP086_RS11375
• Protein ID: WP_112741846.1
• Coordinates: 2240339..2240746 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP086_RS11345 (LP086_11250)	2235570..2237399	-	1830	WP_078274936.1	hypothetical protein	-
LP086_RS11350 (LP086_11255)	2237387..2237731	-	345	WP_078274937.1	hypothetical protein	-
LP086_RS11355 (LP086_11260)	2237732..2238538	-	807	WP_112741850.1	hypothetical protein	-
LP086_RS11360 (LP086_11265)	2238592..2239029	-	438	WP_162860346.1	hypothetical protein	-
LP086_RS11365 (LP086_11270)	2238963..2239295	-	333	WP_112741848.1	hypothetical protein	-
LP086_RS11370 (LP086_11275)	2239292..2240263	-	972	WP_112741847.1	phage tail tape measure protein	-
LP086_RS11375 (LP086_11280)	2240339..2240746	-	408	WP_112741846.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP086_RS11380 (LP086_11285)	2240809..2240997	-	189	WP_078274940.1	type II toxin-antitoxin system HicA family toxin	Toxin
LP086_RS11385 (LP086_11290)	2241140..2241355	-	216	WP_078274941.1	hypothetical protein	-
LP086_RS11390 (LP086_11295)	2241357..2241956	-	600	WP_078274942.1	antA/AntB antirepressor family protein	-
LP086_RS11395 (LP086_11300)	2242063..2242269	-	207	WP_264676102.1	DNA-binding protein	-
LP086_RS11400 (LP086_11305)	2242392..2242736	+	345	WP_078274944.1	helix-turn-helix transcriptional regulator	-
LP086_RS11405 (LP086_11310)	2242780..2243532	-	753	WP_078274945.1	hypothetical protein	-
LP086_RS11410 (LP086_11315)	2243610..2243810	-	201	WP_264676324.1	hypothetical protein	-
LP086_RS11415 (LP086_11320)	2243819..2244010	-	192	WP_264676101.1	DNA-binding protein	-
LP086_RS11420 (LP086_11325)	2244025..2244234	-	210	WP_078274960.1	hypothetical protein	-
LP086_RS11425 (LP086_11330)	2244399..2244698	+	300	WP_078274961.1	helix-turn-helix transcriptional regulator	-
LP086_RS11430 (LP086_11335)	2244893..2245180	+	288	WP_078274962.1	ORF6C domain-containing protein	-
LP086_RS11435 (LP086_11340)	2245177..2245596	+	420	WP_112741841.1	S24 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2231102..2245596	14494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7047.13 Da
• Isoelectric Point: 10.3659

>T226323 WP_078274940.1 NZ_CP087837:c2240997-2240809 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Nucleotide

• Length: 189 bp

>T226323 NZ_CP122448:207975-208082 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14756.85 Da
• Isoelectric Point: 4.2244

>AT226323 WP_112741846.1 NZ_CP087837:c2240746-2240339 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Nucleotide

• Length: 408 bp

>AT226323 NZ_CP122448:c207926-207860 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATATTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC