Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2079920..2080569 Replicon chromosome
Accession NZ_CP087837
Organism Moraxella bovis strain SAM68509

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP086_RS10580 Protein ID WP_078274052.1
Coordinates 2079920..2080321 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP086_RS10585 Protein ID WP_112741908.1
Coordinates 2080336..2080569 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP086_RS10545 (LP086_10450) 2075576..2075809 + 234 WP_112741910.1 ASCH domain-containing protein -
LP086_RS10550 (LP086_10455) 2075828..2076004 + 177 WP_228157829.1 ASCH domain-containing protein -
LP086_RS10555 (LP086_10460) 2076001..2076420 + 420 WP_078274047.1 S4 domain-containing protein -
LP086_RS10565 (LP086_10470) 2077156..2077845 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP086_RS10570 (LP086_10475) 2077944..2078774 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP086_RS10575 (LP086_10480) 2078896..2079396 - 501 WP_112741909.1 WG repeat-containing protein -
LP086_RS10580 (LP086_10485) 2079920..2080321 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP086_RS10585 (LP086_10490) 2080336..2080569 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP086_RS10590 (LP086_10495) 2080617..2082716 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP086_RS10595 (LP086_10500) 2082937..2083530 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP086_RS10600 (LP086_10505) 2083550..2084542 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP086_RS10605 (LP086_10510) 2084724..2085173 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226322 WP_078274052.1 NZ_CP087837:c2080321-2079920 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226322 NZ_CP122443:89088-89375 [Enterobacter ludwigii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226322 WP_112741908.1 NZ_CP087837:c2080569-2080336 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226322 NZ_CP122443:88849-89088 [Enterobacter ludwigii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References