Detailed information of TA system TA226319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1758458..1759010
• Replicon: chromosome
• Accession: NZ_CP087837
• Organism: Moraxella bovis strain SAM68509

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP086_RS08755
• Protein ID: WP_029102268.1
• Coordinates: 1758458..1758736 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP086_RS08760
• Protein ID: WP_078273473.1
• Coordinates: 1758723..1759010 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP086_RS08725 (LP086_08640)	1754445..1755221	-	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-
LP086_RS08730 (LP086_08645)	1755333..1755683	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP086_RS08735 (LP086_08650)	1755831..1756346	+	516	WP_115369660.1	hypothetical protein	-
LP086_RS08740 (LP086_08655)	1756339..1756629	+	291	WP_264676229.1	hypothetical protein	-
LP086_RS08745 (LP086_08660)	1756842..1757507	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP086_RS08750 (LP086_08665)	1757707..1758363	+	657	WP_078273472.1	YqiJ family protein	-
LP086_RS08755 (LP086_08670)	1758458..1758736	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP086_RS08760 (LP086_08675)	1758723..1759010	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP086_RS08765 (LP086_08680)	1759020..1760750	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP086_RS08770	1760794..1760919	-	126	WP_264676709.1	hypothetical protein	-
LP086_RS08775 (LP086_08685)	1760948..1762447	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP086_RS08780 (LP086_08690)	1762526..1763575	-	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226319 WP_029102268.1 NZ_CP087837:1758458-1758736 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226319 NZ_CP122442:5077869-5078189 [Enterobacter ludwigii]
ATGCAAACCACAACTGTACCGGCCACGTTGCCGGTTTCATCACGCCTGTCTCCCGTCCAGGTGTGGCAACAACTGTTAAC
GTATCTACTGGAACACCATTACGGCCTGACGCTTAACGATACGCCATTTCATGATGACGCATCCATAGAGGAACATATCG
AAGCGGGAATAACGCTTGCTGATGCGGTGAATTTCCTGGTTGAACGCTATGAGCTGGTGCGCACTGACCGCAAAGGATTC
ACTTGGCAGGAGCAAACCCCATTTCTGACCGCTACAGATTTTCTCAGAGCCAGACGAGCTACCGGGCTGATGAATACTTA
A

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226319 WP_078273473.1 NZ_CP087837:1758723-1759010 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226319 NZ_CP122442:5077467-5077802 [Enterobacter ludwigii]
ATGAATAAAGACGCGACCCAAATCTGGGGTCTTAATCGAGATATCACACCATGCTTCGGAGCCCGACTGGTGCAGGAAGG
TAACCGTCTGCATTTTCTGGCGGACCGGGCAGGATTCAATGGTTCGTTCAGTGAGATGCAGGCCCGAGATCTGGATGAAG
CCTTTCCGCATTTTGTCGCGCATATGGAATTGATGTTGCTCTCCGGTGAGCTCAATCCCCGGTACTCGCACTGTGTCACG
TTGTATCGTAACGGGCTGACTTGTGAAGCCGATACGCTGGGCAGTTATGGGTATGTATATATCGCAATTTATCCCTCAAA
TCAGGTTAAAGCCTGA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3