Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1424943..1425600 Replicon chromosome
Accession NZ_CP087837
Organism Moraxella bovis strain SAM68509

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP086_RS06995 Protein ID WP_264676287.1
Coordinates 1424943..1425125 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP086_RS07000 Protein ID WP_264676286.1
Coordinates 1425187..1425600 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP086_RS06970 (LP086_06900) 1420916..1422313 - 1398 WP_264676292.1 phage terminase large subunit -
LP086_RS06975 (LP086_06905) 1422313..1422852 - 540 WP_264676291.1 terminase small subunit -
LP086_RS06980 (LP086_06910) 1422966..1423175 + 210 WP_264676290.1 hypothetical protein -
LP086_RS06985 (LP086_06915) 1423212..1423412 + 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP086_RS06990 (LP086_06920) 1423839..1424543 - 705 WP_264676288.1 BRO family protein -
LP086_RS06995 (LP086_06925) 1424943..1425125 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP086_RS07000 (LP086_06930) 1425187..1425600 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP086_RS07005 (LP086_06935) 1425611..1426012 - 402 WP_264676285.1 antiterminator Q family protein -
LP086_RS07010 (LP086_06940) 1425996..1426217 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP086_RS07015 (LP086_06945) 1426214..1426369 - 156 WP_264676283.1 hypothetical protein -
LP086_RS07020 (LP086_06950) 1426511..1426990 - 480 WP_264676694.1 recombination protein NinB -
LP086_RS07025 (LP086_06955) 1427298..1427576 - 279 WP_264676282.1 hypothetical protein -
LP086_RS07030 (LP086_06960) 1427573..1427980 - 408 WP_264676695.1 VRR-NUC domain-containing protein -
LP086_RS07035 (LP086_06965) 1427977..1428585 - 609 WP_078273440.1 hypothetical protein -
LP086_RS07040 (LP086_06970) 1428582..1429391 - 810 WP_264676696.1 replication protein -
LP086_RS07045 (LP086_06975) 1429388..1430071 - 684 WP_264676189.1 Rha family transcriptional regulator -
LP086_RS07050 (LP086_06980) 1430139..1430414 - 276 WP_112742261.1 YdaS family helix-turn-helix protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1380962..1443981 63019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226317 WP_264676287.1 NZ_CP087837:1424943-1425125 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226317 NZ_CP122442:3221825-3222043 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226317 WP_264676286.1 NZ_CP087837:1425187-1425600 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226317 NZ_CP122442:3221423-3221797 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References