Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 438443..439095 Replicon chromosome
Accession NZ_CP087837
Organism Moraxella bovis strain SAM68509

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP086_RS02225 Protein ID WP_078275188.1
Coordinates 438703..439095 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP086_RS02220 Protein ID WP_264675982.1
Coordinates 438443..438706 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP086_RS02190 (LP086_02180) 433728..435062 + 1335 WP_112741795.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP086_RS02195 (LP086_02185) 435206..435499 + 294 WP_029103533.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP086_RS02200 (LP086_02190) 435492..435764 + 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP086_RS02205 (LP086_02195) 435829..436284 - 456 WP_264675985.1 type IV secretion protein Rhs -
LP086_RS02210 (LP086_02200) 436369..436746 + 378 WP_264675984.1 hypothetical protein -
LP086_RS02215 (LP086_02205) 437104..438363 + 1260 WP_264675983.1 replication-associated recombination protein A -
LP086_RS02220 (LP086_02210) 438443..438706 + 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP086_RS02225 (LP086_02215) 438703..439095 + 393 WP_078275188.1 type II toxin-antitoxin system VapC family toxin Toxin
LP086_RS02230 (LP086_02220) 439218..439748 + 531 WP_078275187.1 HI_0552 family protein -
LP086_RS02235 (LP086_02225) 439745..440311 - 567 WP_078275186.1 hypothetical protein -
LP086_RS02240 (LP086_02230) 440314..440550 - 237 WP_078275185.1 sulfurtransferase TusA -
LP086_RS02245 (LP086_02235) 440547..441005 - 459 WP_078275184.1 acyl-CoA thioesterase -
LP086_RS02250 (LP086_02240) 441085..442107 - 1023 WP_078275183.1 hypothetical protein -
LP086_RS02255 (LP086_02245) 442138..443016 - 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP086_RS02260 (LP086_02250) 443062..444003 - 942 WP_078275181.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14689.79 Da        Isoelectric Point: 4.7370

>T226315 WP_078275188.1 NZ_CP087837:438703-439095 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226315 NZ_CP122442:c1867174-1866863 [Enterobacter ludwigii]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGATAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226315 WP_264675982.1 NZ_CP087837:438443-438706 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226315 NZ_CP122442:c1866866-1866447 [Enterobacter ludwigii]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References