Detailed information of TA system TA226312

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 52672..53301
• Replicon: plasmid unnamed1
• Accession: NZ_CP087831
• Organism: Moraxella bovis strain SAM102599

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP092_RS15325
• Protein ID: WP_264688770.1
• Coordinates: 53110..53301 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP092_RS15320
• Protein ID: WP_264688769.1
• Coordinates: 52672..53076 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP092_RS15315 (LP092_15185)	51991..52596	-	606	WP_264697420.1	hypothetical protein	-
LP092_RS15320 (LP092_15190)	52672..53076	-	405	WP_264688769.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP092_RS15325 (LP092_15195)	53110..53301	-	192	WP_264688770.1	type II toxin-antitoxin system HicA family toxin	Toxin
LP092_RS15330 (LP092_15200)	53493..54821	-	1329	WP_264697422.1	DNA-binding protein	-
LP092_RS15335 (LP092_15205)	54849..55091	-	243	WP_264675870.1	helix-turn-helix transcriptional regulator	-
LP092_RS15340 (LP092_15210)	55323..56000	+	678	WP_264675869.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..129623	129623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7027.10 Da
• Isoelectric Point: 11.0174

>T226312 WP_264688770.1 NZ_CP087831:c53301-53110 [Moraxella bovis]
MASSREVIKIIKADGWYRVKSNGGSHQQFKHPTKKGRVTVPHPKKDLAQPTIDSIMRQAGLSD

Nucleotide

• Length: 192 bp

>T226312 NZ_CP122407:5588539-5588955 [Rugamonas sp. DEMB1]
ATGATCGTTCTCGATACCAATGTCGTTTCCGAAGCGATGAAGCCCGAGCCGCACCCCGCAGTGCGGGCTTGGCTGAACAA
GCAAGTTGCCGAAACGCTGTATCTGTCCAGCGTGACGCTCGCCGAGTTGCTGTTTGGCATACGGGCACTTCCGGCCGGCA
AACGCAAGGACACGTTGGCGCGGACCCTCGACGGTCTCATGGTGCCTTTTAGGGATCGGGTGCTGCCGTTTGACGTCGAT
GCGGCGCGGCACTATGCCGACCTGGCCGTCGCAGCCAAAGTCGCCGGGCGCGGCTTTCCAACACCGGATGGTTACATTGC
CGCAATTGCGGTCTCGCGTAGGTTCATCGTCGCGTCGCGCGATACCGCGCCCTACCAAGCCGCCGGTGTCACCGTCATCA
ATCCGTGGCAATCGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15038.16 Da
• Isoelectric Point: 4.7053

>AT226312 WP_264688769.1 NZ_CP087831:c53076-52672 [Moraxella bovis]
MLYPIAILKGDDKTAHGIFFPDVPNLASACDDLQDVHKMALECLDVHFSGLVEDGEEIPLPTNFDAHTQNSQFDGMMWAW
VDVDLSKYDVKSHKINITLPNYLIAKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Nucleotide

• Length: 405 bp

>AT226312 NZ_CP122407:5588288-5588542 [Rugamonas sp. DEMB1]
ATGGCAATGCTAACAGTACGCAACCTGCCCGACGAGGTGCACCGGGCGTTGCGCGCGAGGGCCGCTCAACACGGGCACAG
CACGGAGGCCGAAGTTCGCGCCATTCTGTCCAATGCGGTGAAGCCGGAGGCGCGCCTTCGCATGGGTGACGTCTTGGCGG
CATTGGGCCGCGAAATCGGTCTGACGAACGAGGATGTCGAGTCCCTCACCCAAACAAGGGACAGAACACCGGCCGAGCCG
ATGGGGCTGGAATGA