Detailed information of TA system TA226310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2456183..2456741
• Replicon: chromosome
• Accession: NZ_CP087830
• Organism: Moraxella bovis strain SAM102599

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP092_RS12540
• Protein ID: WP_228157760.1
• Coordinates: 2456183..2456455 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP092_RS12545
• Protein ID: WP_029103533.1
• Coordinates: 2456448..2456741 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP092_RS12500 (LP092_12390)	2451397..2451633	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP092_RS12505 (LP092_12395)	2451636..2452202	+	567	WP_078275186.1	hypothetical protein	-
LP092_RS12510 (LP092_12400)	2452199..2452729	-	531	WP_078275187.1	HI_0552 family protein	-
LP092_RS12515 (LP092_12405)	2452852..2453244	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP092_RS12520 (LP092_12410)	2453241..2453504	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP092_RS12525 (LP092_12415)	2453584..2454843	-	1260	WP_264697062.1	replication-associated recombination protein A	-
LP092_RS12530 (LP092_12420)	2455201..2455578	-	378	WP_264675984.1	hypothetical protein	-
LP092_RS12535 (LP092_12425)	2455663..2456118	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP092_RS12540 (LP092_12430)	2456183..2456455	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP092_RS12545 (LP092_12435)	2456448..2456741	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP092_RS12550 (LP092_12440)	2456885..2458219	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP092_RS12555 (LP092_12445)	2458428..2459144	-	717	WP_078275193.1	hypothetical protein	-
LP092_RS12560 (LP092_12450)	2459165..2459776	-	612	WP_112741794.1	methyltransferase	-
LP092_RS12565 (LP092_12455)	2459896..2461230	+	1335	WP_078275195.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226310 WP_228157760.1 NZ_CP087830:c2456455-2456183 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226310 NZ_CP122407:c4933336-4933151 [Rugamonas sp. DEMB1]
GTGAAGCAGAGCGAGTTCAGGCGATGGCTTGGAGAGCAAGGTGCGACCTTCAAGGACGGCACCAATCATCTGAAGGTCTA
TCTGAATGGCAAGCAAACCGTCATGCCCAGACATCCGAGCCACGAAATTGGCGAGCGTTTAAGGCAGGCAGTCTTGAAAC
AGTTAGGATTGAAAACGGGGAAGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226310 WP_029103533.1 NZ_CP087830:c2456741-2456448 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226310 NZ_CP122407:c4933088-4932675 [Rugamonas sp. DEMB1]
ATGCGCTACCCCGTGAAGATCGAGCAAGATGGCGAGGGCTGGTTCGCCTCCGTCCCTGCCATTCCCGAAGCACTGACCAG
CGGCCCCAGCGCGGAGGCCGCGCTGGCGATGGCCAAGGACGCGTTGATCACATCGATGGACTTCTATTTTGAGGACGGCC
GCCCCGTGCCCTTGCCCGGTGATATCGCCGAGGGGGAGTATCATGTCGACCTGCCCGCCAGCATGTGGGCCAAGGTGCTT
CTACTGAACGAAATGCTGGCGCAACAGAAGCGCCCGACCGATCTGGCCCGCCTGCTGGGCGCCAAACTGCAGGACGTGCA
GCGCTTGTTTGACTTGGCGCACCCGACCAAAATCGACAAAGTGGAGCAGGCGCTCAACGCCTTGGGCAAGCATCTGGTGA
TGGCAGCCAGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6