Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2342347..2343005 Replicon chromosome
Accession NZ_CP087830
Organism Moraxella bovis strain SAM102599

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP092_RS11865 Protein ID WP_078274940.1
Coordinates 2342817..2343005 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP092_RS11860 Protein ID WP_112741846.1
Coordinates 2342347..2342754 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP092_RS11830 (LP092_11730) 2337578..2339407 - 1830 WP_078274936.1 hypothetical protein -
LP092_RS11835 (LP092_11735) 2339395..2339739 - 345 WP_078274937.1 hypothetical protein -
LP092_RS11840 (LP092_11740) 2339740..2340546 - 807 WP_112741850.1 hypothetical protein -
LP092_RS11845 (LP092_11745) 2340600..2341037 - 438 WP_162860346.1 hypothetical protein -
LP092_RS11850 (LP092_11750) 2340971..2341303 - 333 WP_112741848.1 hypothetical protein -
LP092_RS11855 (LP092_11755) 2341300..2342271 - 972 WP_112741847.1 phage tail tape measure protein -
LP092_RS11860 (LP092_11760) 2342347..2342754 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP092_RS11865 (LP092_11765) 2342817..2343005 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP092_RS11870 (LP092_11770) 2343148..2343363 - 216 WP_078274941.1 hypothetical protein -
LP092_RS11875 (LP092_11775) 2343365..2343964 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP092_RS11880 (LP092_11780) 2344071..2344277 - 207 WP_264676102.1 DNA-binding protein -
LP092_RS11885 (LP092_11785) 2344400..2344744 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP092_RS11890 (LP092_11790) 2344788..2345540 - 753 WP_078274945.1 hypothetical protein -
LP092_RS11895 (LP092_11795) 2345618..2345818 - 201 WP_264676324.1 hypothetical protein -
LP092_RS11900 (LP092_11800) 2345827..2346018 - 192 WP_264676101.1 DNA-binding protein -
LP092_RS11905 (LP092_11805) 2346033..2346242 - 210 WP_078274960.1 hypothetical protein -
LP092_RS11910 (LP092_11810) 2346407..2346706 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP092_RS11915 (LP092_11815) 2346901..2347188 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP092_RS11920 (LP092_11820) 2347185..2347604 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2334834..2347604 12770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226308 WP_078274940.1 NZ_CP087830:c2343005-2342817 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226308 NZ_CP122407:c4303147-4302800 [Rugamonas sp. DEMB1]
GTGGTGAGCCGCGTCAAGTTTGGACGGGGCGACATCGTCATGGTCAATCTCGATCCGACCGAAGGTCACGAACAAAGAGG
CATGCGGCCCGCGCTGGTGCTCTCCACGAGTGCGTTTAACGCCTTGGGTGTCGTGCTGGTGGCGCCAATTACGCAGGGCG
GAGATTTTTCGCGCCATGCTGGTTTCGCGGCCTCGTTGAGTGGGGCGGGAACGAAAACGCAAGGCGTGGCCCTGGTCAAT
CAGGTGCATATGCTTGACTTTGAGGCGCGAAAGGCGAGGCGTGTAGAGACGGTGCCGGAATCGGTTGTCGATGATGCGCT
TGCGCGTCTTCGCGCAATCACCGACTAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226308 WP_112741846.1 NZ_CP087830:c2342754-2342347 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226308 NZ_CP122407:c4303392-4303141 [Rugamonas sp. DEMB1]
ATGGAACTCTCAATTCAGAAGTGGGGCAACAGCGCTGCAGTTCGTCTGCCTACCGAGTTGCTGGGCATACTCAAGGTCAC
ATTGGGCGACAAGCTGAGCGTCAACGTACAGCCTGGCGGCGTCTTGCTAAAGGCGGCGCGGCCTGCTTACTCGTTGGCCG
ACTTGGTGGCCCAGTGCGACCCTAACGCCCCGGAGCCGGCCGATATGGCCGCCTGGACCAGCGTGGCGCCCATGGGACGT
GAAACGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References